Evaluation Of Algorithms Of Anti- HIV Antibody Tests
Research question: Can alternate algorithms be used in place of conventional algorithm for epidemiological studies of HIV infection with less expenses? Objective: To compare the results of HIV sero- prevalence as determined by test algorithms combining three kits with conventional test algorithm. S...
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Wolters Kluwer Medknow Publications
1997-01-01
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Series: | Indian Journal of Community Medicine |
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doaj-6b6ddf441014479eb2addf983fbe7ab92020-11-25T00:53:11ZengWolters Kluwer Medknow PublicationsIndian Journal of Community Medicine0970-02181998-35811997-01-012225457Evaluation Of Algorithms Of Anti- HIV Antibody Tests Paranjape R.SKulkarni S.SChanda SumitMehendale S.MJawadekar S.SPratinidhi A.KRodrigues J.JResearch question: Can alternate algorithms be used in place of conventional algorithm for epidemiological studies of HIV infection with less expenses? Objective: To compare the results of HIV sero- prevalence as determined by test algorithms combining three kits with conventional test algorithm. Study design: Cross â€" sectional. Participants: 282 truck drivers. Statistical analysis: Sensitivity and specificity analysis and predictive values. Results: Three different algorithms that do not include Western Blot (WB) were compared with the conventional algorithm, in a truck driver population with 5.6% prevalence of HIV â€"I infection. Algorithms with one EIA (Genetic Systems or Biotest) and a rapid test (immunocomb) or with two EIAs showed 100% positive predictive value in relation to the conventional algorithm. Using an algorithm with EIA as screening test and a rapid test as a confirmatory test was 50 to 70% less expensive than the conventional algorithm per positive scrum sample. These algorithms obviate the interpretation of indeterminate results and also give differential diagnosis of HIV-2 infection. Alternate algorithms are ideally suited for community based control programme in developing countries. Application of these algorithms in population with low prevalence should also be studied in order to evaluate universal applicability.http://www.ijcm.org.in/article.asp?issn=0970-0218;year=1997;volume=22;issue=2;spage=54;epage=57;aulast=Paranjape;type=0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paranjape R.S Kulkarni S.S Chanda Sumit Mehendale S.M Jawadekar S.S Pratinidhi A.K Rodrigues J.J |
spellingShingle |
Paranjape R.S Kulkarni S.S Chanda Sumit Mehendale S.M Jawadekar S.S Pratinidhi A.K Rodrigues J.J Evaluation Of Algorithms Of Anti- HIV Antibody Tests Indian Journal of Community Medicine |
author_facet |
Paranjape R.S Kulkarni S.S Chanda Sumit Mehendale S.M Jawadekar S.S Pratinidhi A.K Rodrigues J.J |
author_sort |
Paranjape R.S |
title |
Evaluation Of Algorithms Of Anti- HIV Antibody Tests |
title_short |
Evaluation Of Algorithms Of Anti- HIV Antibody Tests |
title_full |
Evaluation Of Algorithms Of Anti- HIV Antibody Tests |
title_fullStr |
Evaluation Of Algorithms Of Anti- HIV Antibody Tests |
title_full_unstemmed |
Evaluation Of Algorithms Of Anti- HIV Antibody Tests |
title_sort |
evaluation of algorithms of anti- hiv antibody tests |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Community Medicine |
issn |
0970-0218 1998-3581 |
publishDate |
1997-01-01 |
description |
Research question: Can alternate algorithms be used in place of conventional algorithm for epidemiological studies of HIV infection with less expenses? Objective: To compare the results of HIV sero- prevalence as determined by test algorithms combining three kits with conventional test algorithm. Study design: Cross â€" sectional. Participants: 282 truck drivers. Statistical analysis: Sensitivity and specificity analysis and predictive values. Results: Three different algorithms that do not include Western Blot (WB) were compared with the conventional algorithm, in a truck driver population with 5.6% prevalence of HIV â€"I infection. Algorithms with one EIA (Genetic Systems or Biotest) and a rapid test (immunocomb) or with two EIAs showed 100% positive predictive value in relation to the conventional algorithm. Using an algorithm with EIA as screening test and a rapid test as a confirmatory test was 50 to 70% less expensive than the conventional algorithm per positive scrum sample. These algorithms obviate the interpretation of indeterminate results and also give differential diagnosis of HIV-2 infection. Alternate algorithms are ideally suited for community based control programme in developing countries. Application of these algorithms in population with low prevalence should also be studied in order to evaluate universal applicability. |
url |
http://www.ijcm.org.in/article.asp?issn=0970-0218;year=1997;volume=22;issue=2;spage=54;epage=57;aulast=Paranjape;type=0 |
work_keys_str_mv |
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