On the nature of cancer and why anticancer vaccines don't work
<p>Abstract</p> <p>In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The lack of antigenicity, despite extensive geno...
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BMC
2005-08-01
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| Series: | Cancer Cell International |
| Online Access: | http://www.cancerci.com/content/5/1/25 |
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doaj-6b7de0bcf7ca4c1f9df3af40b84d217b2020-11-25T01:00:52ZengBMCCancer Cell International1475-28672005-08-01512510.1186/1475-2867-5-25On the nature of cancer and why anticancer vaccines don't workPrehn Richmond T<p>Abstract</p> <p>In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The lack of antigenicity, despite extensive genomic instability, could be explained if most tumor mutations occur in silenced genes. A further problem is that an immune reaction against tumor antigens, especially in moderate or low amount, may be stimulatory rather than inhibitory to tumor growth.</p> http://www.cancerci.com/content/5/1/25 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Prehn Richmond T |
| spellingShingle |
Prehn Richmond T On the nature of cancer and why anticancer vaccines don't work Cancer Cell International |
| author_facet |
Prehn Richmond T |
| author_sort |
Prehn Richmond T |
| title |
On the nature of cancer and why anticancer vaccines don't work |
| title_short |
On the nature of cancer and why anticancer vaccines don't work |
| title_full |
On the nature of cancer and why anticancer vaccines don't work |
| title_fullStr |
On the nature of cancer and why anticancer vaccines don't work |
| title_full_unstemmed |
On the nature of cancer and why anticancer vaccines don't work |
| title_sort |
on the nature of cancer and why anticancer vaccines don't work |
| publisher |
BMC |
| series |
Cancer Cell International |
| issn |
1475-2867 |
| publishDate |
2005-08-01 |
| description |
<p>Abstract</p> <p>In this essay I suggest that the major difficulty in producing effective anti-cancer vaccines lies in the fact that most cancers have little immunogenicity because of a basic paucity of tumor-specific antigenicity. The lack of antigenicity, despite extensive genomic instability, could be explained if most tumor mutations occur in silenced genes. A further problem is that an immune reaction against tumor antigens, especially in moderate or low amount, may be stimulatory rather than inhibitory to tumor growth.</p> |
| url |
http://www.cancerci.com/content/5/1/25 |
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