| Summary: | Zinc oxide nanoparticles (ZnO NPs) are applied in various applications in catalysis, biosensing, imaging, and as antibacterial agents. Here we to prepare ZnO nanomaterials decorated by <i>γ</i>-amino butyric acid (GABA), curcumin derivatives (CurBF<sub>2</sub>) and silver nanoparticles (CurBF<sub>2</sub>-AgNPs). The structures of all ZnO nanostructures were characterized using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), UV–VIS spectrophotometry, fluorescence spectrophotometry, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HR-TEM). Further, their antibacterial activities against Gram-negative (<i>Escherichia coli</i>) and Gram-positive (<i>Staphylococcus aureus</i>) bacteria were investigated through analysis of minimum inhibitory concentration (MIC) method. Among the prepared nanostructures, the ZnO NPs-GABA/CurBF<sub>2</sub>-AgNPs showed excellent antibacterial activity against both Gram-positive and -negative bacteria. ZnO NPs fabricated here may have potential use in future anti-bacterial compositions and coatings technologies.
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