Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats
The objective of this study was to determine histomorphological change of seminiferous tubules, sperm quality and testosterone level after administration and cessation of pegagan extract. The research used 4x2 factorial complete randomized design, the first factor was dose-administration duration an...
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Diponegoro University, Faculty of Animal and Agricultural Sciences
2018-08-01
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doaj-6b99d02e70834e10b3b3f0633c828a672020-11-25T02:16:54ZengDiponegoro University, Faculty of Animal and Agricultural SciencesJournal of the Indonesian Tropical Animal Agriculture2087-82732460-62782018-08-0143321822910.14710/jitaa.43.3.218-22913703Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in ratsN. Solihati0B. Purwantara1I. Supriatna2A. Winarto3Faculty of Animal Husbandry, Universitas Padjadjaran Bandung Jl. Raya Bandung-Sumedang KM 21, Jatinagor Sumedang, West JavaFaculty of Veterinary Medicine, Institut Pertanian Bogor Jl. Agatis, Dramaga Campus, Bogor 16680Faculty of Veterinary Medicine, Institut Pertanian Bogor Jl. Agatis, Dramaga Campus, Bogor 16680Faculty of Veterinary Medicine, Institut Pertanian Bogor Jl. Agatis, Dramaga Campus, Bogor 16680The objective of this study was to determine histomorphological change of seminiferous tubules, sperm quality and testosterone level after administration and cessation of pegagan extract. The research used 4x2 factorial complete randomized design, the first factor was dose-administration duration and the second factor was cessation length of pegagan extract. Parameters consisted of degree of spermatogenesis, sperm quality (motility, concentration and abnormality), and testosterone level. The data were processed using analysis of variance and Duncan’s test. Results showed that there was no interaction between dose-administration duration and cessation length. There was no significant difference of dose-administration duration of pegagan on degrees of spermatogenesis, sperm motility and testosterone level. Cessation length did not significantly affect degrees of spermatogenesis, sperm motility, and testosterone level although these results indicated that cessation of pegagan extract for 12 days increased degrees of spermatogenesis and sperm motility, indicated the antifertility potency of pegagan extract. In conclusion, Pegagan extract has potency as anti-fertility agent although the degree of spermatogenesis, sperm quality and testosterone levels were still in the normal range for the reproductive process and not irreversible, and pegagan could be explored as an reversible anti-fertility agent.https://ejournal.undip.ac.id/index.php/jitaa/article/view/16063histomorphological changepegagan extractsperm qualitytestosterone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
N. Solihati B. Purwantara I. Supriatna A. Winarto |
spellingShingle |
N. Solihati B. Purwantara I. Supriatna A. Winarto Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats Journal of the Indonesian Tropical Animal Agriculture histomorphological change pegagan extract sperm quality testosterone |
author_facet |
N. Solihati B. Purwantara I. Supriatna A. Winarto |
author_sort |
N. Solihati |
title |
Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats |
title_short |
Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats |
title_full |
Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats |
title_fullStr |
Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats |
title_full_unstemmed |
Histomorphological changes, sperm quality and testosterone level after administration and cessation of Pegagan (Centella asiatica) extract in rats |
title_sort |
histomorphological changes, sperm quality and testosterone level after administration and cessation of pegagan (centella asiatica) extract in rats |
publisher |
Diponegoro University, Faculty of Animal and Agricultural Sciences |
series |
Journal of the Indonesian Tropical Animal Agriculture |
issn |
2087-8273 2460-6278 |
publishDate |
2018-08-01 |
description |
The objective of this study was to determine histomorphological change of seminiferous tubules, sperm quality and testosterone level after administration and cessation of pegagan extract. The research used 4x2 factorial complete randomized design, the first factor was dose-administration duration and the second factor was cessation length of pegagan extract. Parameters consisted of degree of spermatogenesis, sperm quality (motility, concentration and abnormality), and testosterone level. The data were processed using analysis of variance and Duncan’s test. Results showed that there was no interaction between dose-administration duration and cessation length. There was no significant difference of dose-administration duration of pegagan on degrees of spermatogenesis, sperm motility and testosterone level. Cessation length did not significantly affect degrees of spermatogenesis, sperm motility, and testosterone level although these results indicated that cessation of pegagan extract for 12 days increased degrees of spermatogenesis and sperm motility, indicated the antifertility potency of pegagan extract. In conclusion, Pegagan extract has potency as anti-fertility agent although the degree of spermatogenesis, sperm quality and testosterone levels were still in the normal range for the reproductive process and not irreversible, and pegagan could be explored as an reversible anti-fertility agent. |
topic |
histomorphological change pegagan extract sperm quality testosterone |
url |
https://ejournal.undip.ac.id/index.php/jitaa/article/view/16063 |
work_keys_str_mv |
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