Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes

Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehi...

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Main Authors: Francesca Posa, Adriana Di Benedetto, Giampietro Ravagnan, Elisabetta Ada Cavalcanti-Adam, Lorenzo Lo Muzio, Gianluca Percoco, Giorgio Mori
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Materials
Subjects:
Online Access:https://www.mdpi.com/1996-1944/13/20/4471
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spelling doaj-6ba2eb818da94d43a142fdb19c7353b52020-11-25T03:53:53ZengMDPI AGMaterials1996-19442020-10-01134471447110.3390/ma13204471Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of OligostilbenesFrancesca Posa0Adriana Di Benedetto1Giampietro Ravagnan2Elisabetta Ada Cavalcanti-Adam3Lorenzo Lo Muzio4Gianluca Percoco5Giorgio Mori6Department of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyGlures srl. Unità Operativa di Napoli, Spin off Accademico dell’Università di Venezia Cà Foscari, Via delle Industrie 19b-30175 Venezia, ItalyDepartment of Biophysical Chemistry, Heidelberg University and Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, GermanyDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDepartment of Mechanics, Mathematics and Management, Polytechnic University of Bari, Via E. Orabona 4, 70125 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, ItalyDiseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.https://www.mdpi.com/1996-1944/13/20/4471bonemesenchymal stem cellsbiomaterialpolycarbonateresveratrolpolydatin
collection DOAJ
language English
format Article
sources DOAJ
author Francesca Posa
Adriana Di Benedetto
Giampietro Ravagnan
Elisabetta Ada Cavalcanti-Adam
Lorenzo Lo Muzio
Gianluca Percoco
Giorgio Mori
spellingShingle Francesca Posa
Adriana Di Benedetto
Giampietro Ravagnan
Elisabetta Ada Cavalcanti-Adam
Lorenzo Lo Muzio
Gianluca Percoco
Giorgio Mori
Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
Materials
bone
mesenchymal stem cells
biomaterial
polycarbonate
resveratrol
polydatin
author_facet Francesca Posa
Adriana Di Benedetto
Giampietro Ravagnan
Elisabetta Ada Cavalcanti-Adam
Lorenzo Lo Muzio
Gianluca Percoco
Giorgio Mori
author_sort Francesca Posa
title Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
title_short Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
title_full Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
title_fullStr Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
title_full_unstemmed Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes
title_sort bioengineering bone tissue with 3d printed scaffolds in the presence of oligostilbenes
publisher MDPI AG
series Materials
issn 1996-1944
publishDate 2020-10-01
description Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.
topic bone
mesenchymal stem cells
biomaterial
polycarbonate
resveratrol
polydatin
url https://www.mdpi.com/1996-1944/13/20/4471
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