Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.
mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy that is required for survival to mTOR inhibition. In RCC4...
Main Authors: | Kevin Bray, Robin Mathew, Alexandria Lau, Jurre J Kamphorst, Jing Fan, Jim Chen, Hsin-Yi Chen, Anahita Ghavami, Mark Stein, Robert S DiPaola, Donna Zhang, Joshua D Rabinowitz, Eileen White |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3406086?pdf=render |
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