Is sodium current present in human sinoatrial node cells?

Is sodium current present in human sinoatrial node cells?

<p>Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I<sub>Na</sub>) plays a role in the pacemaker activity of the human sinoatrial node. Rece...

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Main Author: Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
Format: Article
Language:English
Published: Ivyspring International Publisher 2009-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v05p0201.htm
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spelling doaj-6bb536ace8a4499488af429e1f903a542020-11-24T22:47:34ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882009-01-0152201204Is sodium current present in human sinoatrial node cells?Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan<p>Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I<sub>Na</sub>) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform patch-clamp experiments on single pacemaker cells isolated from a human sinoatrial node. In 2 out of the 3 cells measured, we observed large inward currents with characteristics of I<sub>Na</sub>. Although we were unable to analyze the current in detail, our findings provide strong evidence that I<sub>Na</sub> is present in human sinoatrial node pacemaker cells, and that this I<sub>Na</sub> is functionally available at potentials negative to -60 mV.</p>http://www.biolsci.org/v05p0201.htm
collection DOAJ
language English
format Article
sources DOAJ
author Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
spellingShingle Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
Is sodium current present in human sinoatrial node cells?
International Journal of Biological Sciences
author_facet Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
author_sort Arie O. Verkerk, Ronald Wilders, Marcel M.G.J. van Borren, Hanno L. Tan
title Is sodium current present in human sinoatrial node cells?
title_short Is sodium current present in human sinoatrial node cells?
title_full Is sodium current present in human sinoatrial node cells?
title_fullStr Is sodium current present in human sinoatrial node cells?
title_full_unstemmed Is sodium current present in human sinoatrial node cells?
title_sort is sodium current present in human sinoatrial node cells?
publisher Ivyspring International Publisher
series International Journal of Biological Sciences
issn 1449-2288
publishDate 2009-01-01
description <p>Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I<sub>Na</sub>) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform patch-clamp experiments on single pacemaker cells isolated from a human sinoatrial node. In 2 out of the 3 cells measured, we observed large inward currents with characteristics of I<sub>Na</sub>. Although we were unable to analyze the current in detail, our findings provide strong evidence that I<sub>Na</sub> is present in human sinoatrial node pacemaker cells, and that this I<sub>Na</sub> is functionally available at potentials negative to -60 mV.</p>
url http://www.biolsci.org/v05p0201.htm
work_keys_str_mv AT arieoverkerkronaldwildersmarcelmgjvanborrenhannoltan issodiumcurrentpresentinhumansinoatrialnodecells
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