Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds. Properties and advantages of monolithic silica HPLC columns are also highlighted in comparison to conventional particle-packed, fused-core, and sub-2...

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Main Authors: Mufarreh Asmari, Xiaoyu Wang, Natalia Casado, Marjan Piponski, Sergiy Kovalenko, Liliya Logoyda, Rasha Sayed Hanafi, Sami El Deeb
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
chiral chromatography
monolithic silica
chiral selector
immobilization
enantiomers
enantiomeric separation
Online Access:https://www.mdpi.com/1420-3049/26/17/5241
id doaj-6bbaa25138e0469c87516c035a1ccd67
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spelling doaj-6bbaa25138e0469c87516c035a1ccd672021-09-09T13:53:14ZengMDPI AGMolecules1420-30492021-08-01265241524110.3390/molecules26175241Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand InteractionMufarreh Asmari0Xiaoyu Wang1Natalia Casado2Marjan Piponski3Sergiy Kovalenko4Liliya Logoyda5Rasha Sayed Hanafi6Sami El Deeb7College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USADepartamento de Tecnología Química y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/Tulipán s/n, Móstoles, 28933 Madrid, SpainReplek Farm Ltd., st. Kozle 188, 1000 Skopje, North MacedoniaDepartment of Organic and Bioorganic Chemistry, Zaporizhzhia State Medical University, Maiakovskyi avenue 26, 69035 Zaporizhzhia, UkraineDepartment of Pharmaceutical Chemistry, I. Horbachevsky Ternopil National Medical University, Maidan Voli 1, 46001 Ternopil, UkraineDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, EgyptInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, 38106 Braunschweig, GermanyThis review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds. Properties and advantages of monolithic silica HPLC columns are also highlighted in comparison to conventional particle-packed, fused-core, and sub-2-µm HPLC columns. Nano-LC capillary monolithic silica columns as well as polymeric-based and hybrid-based monolithic columns are also demonstrated to show good enantioresolution abilities. Methods for introducing the chiral selector into the monolithic silica column in the form of mobile phase additive, by encapsulation and surface coating, or by covalent functionalization are described. The application of molecular modeling methods to elucidate the selector–selectand interaction is discussed. An application for enantiomeric impurity determination is also considered.https://www.mdpi.com/1420-3049/26/17/5241chiral chromatographymonolithic silicachiral selectorimmobilizationenantiomersenantiomeric separation
collection DOAJ
language English
format Article
sources DOAJ
author Mufarreh Asmari
Xiaoyu Wang
Natalia Casado
Marjan Piponski
Sergiy Kovalenko
Liliya Logoyda
Rasha Sayed Hanafi
Sami El Deeb
spellingShingle Mufarreh Asmari
Xiaoyu Wang
Natalia Casado
Marjan Piponski
Sergiy Kovalenko
Liliya Logoyda
Rasha Sayed Hanafi
Sami El Deeb
Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction
Molecules
chiral chromatography
monolithic silica
chiral selector
immobilization
enantiomers
enantiomeric separation
author_facet Mufarreh Asmari
Xiaoyu Wang
Natalia Casado
Marjan Piponski
Sergiy Kovalenko
Liliya Logoyda
Rasha Sayed Hanafi
Sami El Deeb
author_sort Mufarreh Asmari
title Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction
title_short Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction
title_full Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction
title_fullStr Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction
title_full_unstemmed Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction
title_sort chiral monolithic silica-based hplc columns for enantiomeric separation and determination: functionalization of chiral selector and recognition of selector-selectand interaction
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2021-08-01
description This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds. Properties and advantages of monolithic silica HPLC columns are also highlighted in comparison to conventional particle-packed, fused-core, and sub-2-µm HPLC columns. Nano-LC capillary monolithic silica columns as well as polymeric-based and hybrid-based monolithic columns are also demonstrated to show good enantioresolution abilities. Methods for introducing the chiral selector into the monolithic silica column in the form of mobile phase additive, by encapsulation and surface coating, or by covalent functionalization are described. The application of molecular modeling methods to elucidate the selector–selectand interaction is discussed. An application for enantiomeric impurity determination is also considered.
topic chiral chromatography
monolithic silica
chiral selector
immobilization
enantiomers
enantiomeric separation
url https://www.mdpi.com/1420-3049/26/17/5241
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AT xiaoyuwang chiralmonolithicsilicabasedhplccolumnsforenantiomericseparationanddeterminationfunctionalizationofchiralselectorandrecognitionofselectorselectandinteraction
AT nataliacasado chiralmonolithicsilicabasedhplccolumnsforenantiomericseparationanddeterminationfunctionalizationofchiralselectorandrecognitionofselectorselectandinteraction
AT marjanpiponski chiralmonolithicsilicabasedhplccolumnsforenantiomericseparationanddeterminationfunctionalizationofchiralselectorandrecognitionofselectorselectandinteraction
AT sergiykovalenko chiralmonolithicsilicabasedhplccolumnsforenantiomericseparationanddeterminationfunctionalizationofchiralselectorandrecognitionofselectorselectandinteraction
AT liliyalogoyda chiralmonolithicsilicabasedhplccolumnsforenantiomericseparationanddeterminationfunctionalizationofchiralselectorandrecognitionofselectorselectandinteraction
AT rashasayedhanafi chiralmonolithicsilicabasedhplccolumnsforenantiomericseparationanddeterminationfunctionalizationofchiralselectorandrecognitionofselectorselectandinteraction
AT samieldeeb chiralmonolithicsilicabasedhplccolumnsforenantiomericseparationanddeterminationfunctionalizationofchiralselectorandrecognitionofselectorselectandinteraction
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