Haemophagocytic lymphohistiocytosis and the challenge of early diagnosis

Haemophagocytic lymphohistiocytosis and the challenge of early diagnosis

Haemophagocytic lymphohistiocytosis (HLH) is an uncommon, life-threatening hyperinflammatory syndrome in which abnormal, ineffective energising of the immune system causes excessive activation of lymphocytes and macrophages, which can lead to hypercytokinaemia and massive tissue destruction. A high...

Full description

Bibliographic Details
Main Authors: Hoda Mohamed Hammoda, Mahmoud Mohamed Marashi, Hesham Abdalla Mohamed Abdalla, Mahmod El Shahat Awad Makhlof, Manal Sayed Rezzek
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Hamdan Medical Journal
Subjects:
hypercytokinaemia
hyperinflammatory syndrome
lymphohistiocytosis
Online Access:http://www.hamdanjournal.org/article.asp?issn=2227-2437;year=2019;volume=12;issue=2;spage=83;epage=85;aulast=Hammoda
Description
Summary:Haemophagocytic lymphohistiocytosis (HLH) is an uncommon, life-threatening hyperinflammatory syndrome in which abnormal, ineffective energising of the immune system causes excessive activation of lymphocytes and macrophages, which can lead to hypercytokinaemia and massive tissue destruction. A high index of suspicion is necessary for early diagnosis. We report a case of HLH in a 66-year-old woman who presented with fever, pancytopenia and hepatosplenomegaly.
ISSN:2227-2437
2227-247X

Similar Items