Enantioselectivity Effects in Clinical Metabolomics and Lipidomics

Metabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids...

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Main Authors: Regina V. Oliveira, Ana Valéria C. Simionato, Quezia B. Cass
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/26/17/5231
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spelling doaj-6bd3c6592bb24fc1a97f52886c2d612e2021-09-09T13:53:12ZengMDPI AGMolecules1420-30492021-08-01265231523110.3390/molecules26175231Enantioselectivity Effects in Clinical Metabolomics and LipidomicsRegina V. Oliveira0Ana Valéria C. Simionato1Quezia B. Cass2SEPARARE-Núcleo de Pesquisa em Cromatografia, Department of Chemistry, Federal University of São Carlos, Rod. Washington Luiz, Km 235, São Carlos 13565-905, SP, BrazilDepartment of Analytical Chemistry, Institute of Chemistry, University of Campinas, Campinas 13083-970, SP, BrazilSEPARARE-Núcleo de Pesquisa em Cromatografia, Department of Chemistry, Federal University of São Carlos, Rod. Washington Luiz, Km 235, São Carlos 13565-905, SP, BrazilMetabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids have biological activity and have been implicated in various biological processes in physiological conditions. Thus, comprehensive metabolites, and lipids profiling are required to obtain further advances in understanding pathophysiological changes that occur in cells and tissues. Chirality is one of the most important phenomena in living organisms and has attracted long-term interest in medical and natural science. Enantioselective separation plays a pivotal role in understanding the distribution and physiological function of a diversity of chiral bioactive molecules. In this context, it has been the goal of method development for targeted and untargeted metabolomics and lipidomic assays. Herein we will highlight the benefits and challenges involved in these stereoselective analyses for clinical samples.https://www.mdpi.com/1420-3049/26/17/5231metabolomicslipidomicsstereoisomerschiral biomarkerschiral amino acidsLC-MS
collection DOAJ
language English
format Article
sources DOAJ
author Regina V. Oliveira
Ana Valéria C. Simionato
Quezia B. Cass
spellingShingle Regina V. Oliveira
Ana Valéria C. Simionato
Quezia B. Cass
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
Molecules
metabolomics
lipidomics
stereoisomers
chiral biomarkers
chiral amino acids
LC-MS
author_facet Regina V. Oliveira
Ana Valéria C. Simionato
Quezia B. Cass
author_sort Regina V. Oliveira
title Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_short Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_full Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_fullStr Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_full_unstemmed Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
title_sort enantioselectivity effects in clinical metabolomics and lipidomics
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2021-08-01
description Metabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids have biological activity and have been implicated in various biological processes in physiological conditions. Thus, comprehensive metabolites, and lipids profiling are required to obtain further advances in understanding pathophysiological changes that occur in cells and tissues. Chirality is one of the most important phenomena in living organisms and has attracted long-term interest in medical and natural science. Enantioselective separation plays a pivotal role in understanding the distribution and physiological function of a diversity of chiral bioactive molecules. In this context, it has been the goal of method development for targeted and untargeted metabolomics and lipidomic assays. Herein we will highlight the benefits and challenges involved in these stereoselective analyses for clinical samples.
topic metabolomics
lipidomics
stereoisomers
chiral biomarkers
chiral amino acids
LC-MS
url https://www.mdpi.com/1420-3049/26/17/5231
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