Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
Metabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids...
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doaj-6bd3c6592bb24fc1a97f52886c2d612e2021-09-09T13:53:12ZengMDPI AGMolecules1420-30492021-08-01265231523110.3390/molecules26175231Enantioselectivity Effects in Clinical Metabolomics and LipidomicsRegina V. Oliveira0Ana Valéria C. Simionato1Quezia B. Cass2SEPARARE-Núcleo de Pesquisa em Cromatografia, Department of Chemistry, Federal University of São Carlos, Rod. Washington Luiz, Km 235, São Carlos 13565-905, SP, BrazilDepartment of Analytical Chemistry, Institute of Chemistry, University of Campinas, Campinas 13083-970, SP, BrazilSEPARARE-Núcleo de Pesquisa em Cromatografia, Department of Chemistry, Federal University of São Carlos, Rod. Washington Luiz, Km 235, São Carlos 13565-905, SP, BrazilMetabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids have biological activity and have been implicated in various biological processes in physiological conditions. Thus, comprehensive metabolites, and lipids profiling are required to obtain further advances in understanding pathophysiological changes that occur in cells and tissues. Chirality is one of the most important phenomena in living organisms and has attracted long-term interest in medical and natural science. Enantioselective separation plays a pivotal role in understanding the distribution and physiological function of a diversity of chiral bioactive molecules. In this context, it has been the goal of method development for targeted and untargeted metabolomics and lipidomic assays. Herein we will highlight the benefits and challenges involved in these stereoselective analyses for clinical samples.https://www.mdpi.com/1420-3049/26/17/5231metabolomicslipidomicsstereoisomerschiral biomarkerschiral amino acidsLC-MS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Regina V. Oliveira Ana Valéria C. Simionato Quezia B. Cass |
spellingShingle |
Regina V. Oliveira Ana Valéria C. Simionato Quezia B. Cass Enantioselectivity Effects in Clinical Metabolomics and Lipidomics Molecules metabolomics lipidomics stereoisomers chiral biomarkers chiral amino acids LC-MS |
author_facet |
Regina V. Oliveira Ana Valéria C. Simionato Quezia B. Cass |
author_sort |
Regina V. Oliveira |
title |
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics |
title_short |
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics |
title_full |
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics |
title_fullStr |
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics |
title_full_unstemmed |
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics |
title_sort |
enantioselectivity effects in clinical metabolomics and lipidomics |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-08-01 |
description |
Metabolomics and lipidomics have demonstrated increasing importance in underlying biochemical mechanisms involved in the pathogenesis of diseases to identify novel drug targets and/or biomarkers for establishing therapeutic approaches for human health. Particularly, bioactive metabolites and lipids have biological activity and have been implicated in various biological processes in physiological conditions. Thus, comprehensive metabolites, and lipids profiling are required to obtain further advances in understanding pathophysiological changes that occur in cells and tissues. Chirality is one of the most important phenomena in living organisms and has attracted long-term interest in medical and natural science. Enantioselective separation plays a pivotal role in understanding the distribution and physiological function of a diversity of chiral bioactive molecules. In this context, it has been the goal of method development for targeted and untargeted metabolomics and lipidomic assays. Herein we will highlight the benefits and challenges involved in these stereoselective analyses for clinical samples. |
topic |
metabolomics lipidomics stereoisomers chiral biomarkers chiral amino acids LC-MS |
url |
https://www.mdpi.com/1420-3049/26/17/5231 |
work_keys_str_mv |
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_version_ |
1717759629042122752 |