Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly
<b>Introduction:</b> Osteoporosis is increasingly prevalent in the elderly, with fractures mostly occurring in women and men who are older than 55 and 65 years of age, respectively. The aim of this review was to examine the evidence regarding the influence of hormones on bone metabolism,...
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doaj-6bda8e8004ac444ab90da1c69238939e2020-11-25T01:33:26ZengMDPI AGJournal of Clinical Medicine2077-03832019-10-01810156410.3390/jcm8101564jcm8101564Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the ElderlyRossella Cannarella0Federica Barbagallo1Rosita A. Condorelli2Antonio Aversa3Sandro La Vignera4Aldo E. Calogero5Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy<b>Introduction:</b> Osteoporosis is increasingly prevalent in the elderly, with fractures mostly occurring in women and men who are older than 55 and 65 years of age, respectively. The aim of this review was to examine the evidence regarding the influence of hormones on bone metabolism, followed by clinical data of hormonal changes in the elderly, in the attempt to provide possible poorly explored diagnostic and therapeutic candidate targets for the management of primary osteoporosis in the aging population. <b>Material and methods:</b> An extensive Medline search using PubMed, Embase, and Cochrane Library was performed. <b>Results:</b> While the rise in Thyroid-stimulating hormone (TSH) levels has a protective role on bone mass, the decline of estrogen, testosterone, Insulin-like growth factor 1 (IGF1), and vitamin D and the rise of cortisol, parathyroid hormone, and follicle-stimulating hormone (FSH) favor bone loss in the elderly. Particularly, the AA rs6166 FSH receptor (FSHR) genotype, encoding for a more sensitive FSHR than that encoded by the GG one, is associated with low total body mass density (BMD), independently of circulating estrogen. A polyclonal antibody with a FSHR-binding sequence against the β-subunit of murine FSH seems to be effective in ameliorating bone loss in ovariectomized mice. <b>Conclusions:</b> A complete hormonal assessment should be completed for both women and men during bone loss evaluation. Novel possible diagnostic and therapeutic tools might be developed for the management of male and female osteoporosis.https://www.mdpi.com/2077-0383/8/10/1564osteoporosisbone mineral densityfshtestosteronecortisoligf1vitamin d |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rossella Cannarella Federica Barbagallo Rosita A. Condorelli Antonio Aversa Sandro La Vignera Aldo E. Calogero |
spellingShingle |
Rossella Cannarella Federica Barbagallo Rosita A. Condorelli Antonio Aversa Sandro La Vignera Aldo E. Calogero Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly Journal of Clinical Medicine osteoporosis bone mineral density fsh testosterone cortisol igf1 vitamin d |
author_facet |
Rossella Cannarella Federica Barbagallo Rosita A. Condorelli Antonio Aversa Sandro La Vignera Aldo E. Calogero |
author_sort |
Rossella Cannarella |
title |
Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly |
title_short |
Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly |
title_full |
Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly |
title_fullStr |
Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly |
title_full_unstemmed |
Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly |
title_sort |
osteoporosis from an endocrine perspective: the role of hormonal changes in the elderly |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-10-01 |
description |
<b>Introduction:</b> Osteoporosis is increasingly prevalent in the elderly, with fractures mostly occurring in women and men who are older than 55 and 65 years of age, respectively. The aim of this review was to examine the evidence regarding the influence of hormones on bone metabolism, followed by clinical data of hormonal changes in the elderly, in the attempt to provide possible poorly explored diagnostic and therapeutic candidate targets for the management of primary osteoporosis in the aging population. <b>Material and methods:</b> An extensive Medline search using PubMed, Embase, and Cochrane Library was performed. <b>Results:</b> While the rise in Thyroid-stimulating hormone (TSH) levels has a protective role on bone mass, the decline of estrogen, testosterone, Insulin-like growth factor 1 (IGF1), and vitamin D and the rise of cortisol, parathyroid hormone, and follicle-stimulating hormone (FSH) favor bone loss in the elderly. Particularly, the AA rs6166 FSH receptor (FSHR) genotype, encoding for a more sensitive FSHR than that encoded by the GG one, is associated with low total body mass density (BMD), independently of circulating estrogen. A polyclonal antibody with a FSHR-binding sequence against the β-subunit of murine FSH seems to be effective in ameliorating bone loss in ovariectomized mice. <b>Conclusions:</b> A complete hormonal assessment should be completed for both women and men during bone loss evaluation. Novel possible diagnostic and therapeutic tools might be developed for the management of male and female osteoporosis. |
topic |
osteoporosis bone mineral density fsh testosterone cortisol igf1 vitamin d |
url |
https://www.mdpi.com/2077-0383/8/10/1564 |
work_keys_str_mv |
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