Tigecycline application in a 3-month-old infant with multiple drug resistant Klebsiella pneumonia: a case report

• Main Authors: Cheng Peng, Xiaofeng Wang, Jiangwei Zhang, Yi Jiang, Xinlin Hou
• Format: Article
• Language: English
• Published: BMC 2018-06-01
• Series: Gut Pathogens
• Subjects: Multiple drug resistant; Klebsiella pneumoniae; Tigecycline; Pediatric
• Online Access: http://link.springer.com/article/10.1186/s13099-018-0253-x

Abstract Background Tigecycline is an ‘immature’ antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient. Case presentation The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant Klebsiella pneumoniae. Tigecycline was considered as a salvage therapy to control the severe sepsis. The therapy consisted of 3 mg/kg as a loading dose and 1.5 mg/kg Q12 h as a maintenance dose for 26 days. Conclusion Current researches are limited in clinical trials directly focused on children. This therapeutic schedule might be safe for patients who are above 3 months old.