Aging, lifestyle and dementia

Aging, lifestyle and dementia

Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders, and neurodegenerative disease. There is emerging evidence that interventions that improve metabolic health with aging may also be effective for brain health. The most robust interventions are non-pharmaco...

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Main Authors: Devin Wahl, Samantha M. Solon-Biet, Victoria C. Cogger, Luigi Fontana, Stephen J. Simpson, David G. Le Couteur, Rosilene V. Ribeiro
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Metabolic health
Calorie restriction
Alzheimer's disease
Dementia
Aging
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301329
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spelling doaj-6bf0f2e42e554968bf2b530decc0a09b2021-03-22T12:48:13ZengElsevierNeurobiology of Disease1095-953X2019-10-01130104481Aging, lifestyle and dementiaDevin Wahl0Samantha M. Solon-Biet1Victoria C. Cogger2Luigi Fontana3Stephen J. Simpson4David G. Le Couteur5Rosilene V. Ribeiro6Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, Australia; Corresponding authors at: Charles Perkins Centre, The University of Sydney, Johns Hopkins Drive, Camperdown, NSW, Australia.Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, AustraliaCharles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, AustraliaCharles Perkins Centre, University of Sydney, Sydney 2006, AustraliaCharles Perkins Centre, University of Sydney, Sydney 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney 2006, AustraliaCharles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, Australia; Corresponding authors at: Charles Perkins Centre, The University of Sydney, Johns Hopkins Drive, Camperdown, NSW, Australia.Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney 2006, AustraliaAging is the greatest risk factor for most diseases including cancer, cardiovascular disorders, and neurodegenerative disease. There is emerging evidence that interventions that improve metabolic health with aging may also be effective for brain health. The most robust interventions are non-pharmacological and include limiting calorie or protein intake, increasing aerobic exercise, or environmental enrichment. In humans, dietary patterns including the Mediterranean, Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) and Okinawan diets are associated with improved age-related health and may reduce neurodegenerative disease including dementia. Rapamycin, metformin and resveratrol act on nutrient sensing pathways that improve cardiometabolic health and decrease the risk for age-associated disease. There is some evidence that they may reduce the risk for dementia in rodents. There is a growing recognition that improving metabolic function may be an effective way to optimize brain health during aging.http://www.sciencedirect.com/science/article/pii/S0969996119301329Metabolic healthCalorie restrictionAlzheimer's diseaseDementiaAging
collection DOAJ
language English
format Article
sources DOAJ
author Devin Wahl
Samantha M. Solon-Biet
Victoria C. Cogger
Luigi Fontana
Stephen J. Simpson
David G. Le Couteur
Rosilene V. Ribeiro
spellingShingle Devin Wahl
Samantha M. Solon-Biet
Victoria C. Cogger
Luigi Fontana
Stephen J. Simpson
David G. Le Couteur
Rosilene V. Ribeiro
Aging, lifestyle and dementia
Neurobiology of Disease
Metabolic health
Calorie restriction
Alzheimer's disease
Dementia
Aging
author_facet Devin Wahl
Samantha M. Solon-Biet
Victoria C. Cogger
Luigi Fontana
Stephen J. Simpson
David G. Le Couteur
Rosilene V. Ribeiro
author_sort Devin Wahl
title Aging, lifestyle and dementia
title_short Aging, lifestyle and dementia
title_full Aging, lifestyle and dementia
title_fullStr Aging, lifestyle and dementia
title_full_unstemmed Aging, lifestyle and dementia
title_sort aging, lifestyle and dementia
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2019-10-01
description Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders, and neurodegenerative disease. There is emerging evidence that interventions that improve metabolic health with aging may also be effective for brain health. The most robust interventions are non-pharmacological and include limiting calorie or protein intake, increasing aerobic exercise, or environmental enrichment. In humans, dietary patterns including the Mediterranean, Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) and Okinawan diets are associated with improved age-related health and may reduce neurodegenerative disease including dementia. Rapamycin, metformin and resveratrol act on nutrient sensing pathways that improve cardiometabolic health and decrease the risk for age-associated disease. There is some evidence that they may reduce the risk for dementia in rodents. There is a growing recognition that improving metabolic function may be an effective way to optimize brain health during aging.
topic Metabolic health
Calorie restriction
Alzheimer's disease
Dementia
Aging
url http://www.sciencedirect.com/science/article/pii/S0969996119301329
work_keys_str_mv AT devinwahl aginglifestyleanddementia
AT samanthamsolonbiet aginglifestyleanddementia
AT victoriaccogger aginglifestyleanddementia
AT luigifontana aginglifestyleanddementia
AT stephenjsimpson aginglifestyleanddementia
AT davidglecouteur aginglifestyleanddementia
AT rosilenevribeiro aginglifestyleanddementia
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