Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer
Lung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis of lung cancer and better treatment selection for patients. Ce...
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doaj-6bf3056d1095437c90edb43444d81a342020-11-25T00:27:23ZengMDPI AGCancers2072-66942019-06-0111688810.3390/cancers11060888cancers11060888Exo-miRNAs as a New Tool for Liquid Biopsy in Lung CancerOrazio Fortunato0Patrizia Gasparini1Mattia Boeri2Gabriella Sozzi3Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, ItalyTumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, ItalyTumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, ItalyTumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, ItalyLung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis of lung cancer and better treatment selection for patients. Cell-free microRNAs have been detected in biological fluids, such as serum and plasma, and are considered interesting biomarkers for lung cancer screening and detection. Exosomes are nanovesicles of 30−150 nm and can be released by different cell types within the tumor microenvironment. Their exosomal composition reflects that of their parental cells and could be potentially useful as a biomarker for lung cancer diagnosis. This review summarizes the state-of-the-art of circulating microRNAs (miRNAs) in lung cancer, focusing on their potential use in clinical practice. Moreover, we describe the importance of exosomal miRNA cargo in lung cancer detection and their potential role during lung carcinogenesis. Finally, we discuss our experience with the analysis of circulating exosomal miRNAs in the bioMILD screening trial.https://www.mdpi.com/2072-6694/11/6/888microRNAlung cancerexosomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Orazio Fortunato Patrizia Gasparini Mattia Boeri Gabriella Sozzi |
spellingShingle |
Orazio Fortunato Patrizia Gasparini Mattia Boeri Gabriella Sozzi Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer Cancers microRNA lung cancer exosomes |
author_facet |
Orazio Fortunato Patrizia Gasparini Mattia Boeri Gabriella Sozzi |
author_sort |
Orazio Fortunato |
title |
Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer |
title_short |
Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer |
title_full |
Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer |
title_fullStr |
Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer |
title_full_unstemmed |
Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer |
title_sort |
exo-mirnas as a new tool for liquid biopsy in lung cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-06-01 |
description |
Lung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis of lung cancer and better treatment selection for patients. Cell-free microRNAs have been detected in biological fluids, such as serum and plasma, and are considered interesting biomarkers for lung cancer screening and detection. Exosomes are nanovesicles of 30−150 nm and can be released by different cell types within the tumor microenvironment. Their exosomal composition reflects that of their parental cells and could be potentially useful as a biomarker for lung cancer diagnosis. This review summarizes the state-of-the-art of circulating microRNAs (miRNAs) in lung cancer, focusing on their potential use in clinical practice. Moreover, we describe the importance of exosomal miRNA cargo in lung cancer detection and their potential role during lung carcinogenesis. Finally, we discuss our experience with the analysis of circulating exosomal miRNAs in the bioMILD screening trial. |
topic |
microRNA lung cancer exosomes |
url |
https://www.mdpi.com/2072-6694/11/6/888 |
work_keys_str_mv |
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