Differential Virulence of West Nile Strains for American Crows
Crow deaths were observed after West Nile virus (WNV) was introduced into North America, and this phenomenon has subsequently been used to monitor the spread of the virus. To investigate potential differences in the crow virulence of different WNV strains, American Crows were inoculated with Old Wor...
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Centers for Disease Control and Prevention
2004-12-01
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Online Access: | https://wwwnc.cdc.gov/eid/article/10/12/04-0486_article |
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doaj-6c0cd81144434e398fc6a914686eea992020-11-25T00:33:25ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592004-12-0110122161216810.3201/eid1012.040486Differential Virulence of West Nile Strains for American CrowsAaron C. BraultStanley A. LangevinRichard A. BowenNicholas A. PanellaBrad J. BiggerstaffBarry R. MillerNicholas KomarCrow deaths were observed after West Nile virus (WNV) was introduced into North America, and this phenomenon has subsequently been used to monitor the spread of the virus. To investigate potential differences in the crow virulence of different WNV strains, American Crows were inoculated with Old World strains of WNV from Kenya and Australia (Kunjin) and a North American (NY99) WNV genotype. Infection of crows with NY99 genotype resulted in high serum viremia levels and death; the Kenyan and Kunjin genotypes elicited low viremia levels and minimal deaths, but resulted in the generation of neutralizing antibodies capable of providing 100% protection from infection with the NY99 strain. These results suggest that genetic alterations in NY99 WNV are responsible for the crow-virulent phenotype and that increased replication of this strain in crows could spread WNV in North America.https://wwwnc.cdc.gov/eid/article/10/12/04-0486_articleWest Nile virusAmerican CrowsstrainsmortalityvirulenceKunjin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aaron C. Brault Stanley A. Langevin Richard A. Bowen Nicholas A. Panella Brad J. Biggerstaff Barry R. Miller Nicholas Komar |
spellingShingle |
Aaron C. Brault Stanley A. Langevin Richard A. Bowen Nicholas A. Panella Brad J. Biggerstaff Barry R. Miller Nicholas Komar Differential Virulence of West Nile Strains for American Crows Emerging Infectious Diseases West Nile virus American Crows strains mortality virulence Kunjin |
author_facet |
Aaron C. Brault Stanley A. Langevin Richard A. Bowen Nicholas A. Panella Brad J. Biggerstaff Barry R. Miller Nicholas Komar |
author_sort |
Aaron C. Brault |
title |
Differential Virulence of West Nile Strains for American Crows |
title_short |
Differential Virulence of West Nile Strains for American Crows |
title_full |
Differential Virulence of West Nile Strains for American Crows |
title_fullStr |
Differential Virulence of West Nile Strains for American Crows |
title_full_unstemmed |
Differential Virulence of West Nile Strains for American Crows |
title_sort |
differential virulence of west nile strains for american crows |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2004-12-01 |
description |
Crow deaths were observed after West Nile virus (WNV) was introduced into North America, and this phenomenon has subsequently been used to monitor the spread of the virus. To investigate potential differences in the crow virulence of different WNV strains, American Crows were inoculated with Old World strains of WNV from Kenya and Australia (Kunjin) and a North American (NY99) WNV genotype. Infection of crows with NY99 genotype resulted in high serum viremia levels and death; the Kenyan and Kunjin genotypes elicited low viremia levels and minimal deaths, but resulted in the generation of neutralizing antibodies capable of providing 100% protection from infection with the NY99 strain. These results suggest that genetic alterations in NY99 WNV are responsible for the crow-virulent phenotype and that increased replication of this strain in crows could spread WNV in North America. |
topic |
West Nile virus American Crows strains mortality virulence Kunjin |
url |
https://wwwnc.cdc.gov/eid/article/10/12/04-0486_article |
work_keys_str_mv |
AT aaroncbrault differentialvirulenceofwestnilestrainsforamericancrows AT stanleyalangevin differentialvirulenceofwestnilestrainsforamericancrows AT richardabowen differentialvirulenceofwestnilestrainsforamericancrows AT nicholasapanella differentialvirulenceofwestnilestrainsforamericancrows AT bradjbiggerstaff differentialvirulenceofwestnilestrainsforamericancrows AT barryrmiller differentialvirulenceofwestnilestrainsforamericancrows AT nicholaskomar differentialvirulenceofwestnilestrainsforamericancrows |
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