CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespa...

Full description

Bibliographic Details
Main Authors: Qinchuan Wang, Erick O. Hernández-Ochoa, Meera C. Viswanathan, Ian D. Blum, Danh C. Do, Jonathan M. Granger, Kevin R. Murphy, An-Chi Wei, Susan Aja, Naili Liu, Corina M. Antonescu, Liliana D. Florea, C. Conover Talbot, David Mohr, Kathryn R. Wagner, Sergi Regot, Richard M. Lovering, Peisong Gao, Mario A. Bianchet, Mark N. Wu, Anthony Cammarato, Martin F. Schneider, Gabriel S. Bever, Mark E. Anderson
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23549-3
id doaj-6c13420d75db4c89a9f1e7180f0d0576
record_format Article
spelling doaj-6c13420d75db4c89a9f1e7180f0d05762021-05-30T11:14:45ZengNature Publishing GroupNature Communications2041-17232021-05-0112111710.1038/s41467-021-23549-3CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolutionQinchuan Wang0Erick O. Hernández-Ochoa1Meera C. Viswanathan2Ian D. Blum3Danh C. Do4Jonathan M. Granger5Kevin R. Murphy6An-Chi Wei7Susan Aja8Naili Liu9Corina M. Antonescu10Liliana D. Florea11C. Conover Talbot12David Mohr13Kathryn R. Wagner14Sergi Regot15Richard M. Lovering16Peisong Gao17Mario A. Bianchet18Mark N. Wu19Anthony Cammarato20Martin F. Schneider21Gabriel S. Bever22Mark E. Anderson23Department of Medicine, Johns Hopkins School of MedicineDepartment of Biochemistry and Molecular Biology, University of Maryland School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineDepartment of Electrical Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan UniversityDepartment of Neuroscience, Johns Hopkins School of MedicineCenter for Genetic Muscle Disorders, Kennedy Krieger InstituteJohns Hopkins Computational Biology Consulting CoreJohns Hopkins Computational Biology Consulting CoreInstitute for Basic Biomedical Sciences, Johns Hopkins School of MedicineJohns Hopkins School of Medicine Genetic Resources Core FacilityDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Molecular Biology & Genetics, Johns Hopkins School of MedicineDepartment of Orthopaedics, University of Maryland School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineDepartment of Biochemistry and Molecular Biology, University of Maryland School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineDepartment of Medicine, Johns Hopkins School of MedicineNatural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan.https://doi.org/10.1038/s41467-021-23549-3
collection DOAJ
language English
format Article
sources DOAJ
author Qinchuan Wang
Erick O. Hernández-Ochoa
Meera C. Viswanathan
Ian D. Blum
Danh C. Do
Jonathan M. Granger
Kevin R. Murphy
An-Chi Wei
Susan Aja
Naili Liu
Corina M. Antonescu
Liliana D. Florea
C. Conover Talbot
David Mohr
Kathryn R. Wagner
Sergi Regot
Richard M. Lovering
Peisong Gao
Mario A. Bianchet
Mark N. Wu
Anthony Cammarato
Martin F. Schneider
Gabriel S. Bever
Mark E. Anderson
spellingShingle Qinchuan Wang
Erick O. Hernández-Ochoa
Meera C. Viswanathan
Ian D. Blum
Danh C. Do
Jonathan M. Granger
Kevin R. Murphy
An-Chi Wei
Susan Aja
Naili Liu
Corina M. Antonescu
Liliana D. Florea
C. Conover Talbot
David Mohr
Kathryn R. Wagner
Sergi Regot
Richard M. Lovering
Peisong Gao
Mario A. Bianchet
Mark N. Wu
Anthony Cammarato
Martin F. Schneider
Gabriel S. Bever
Mark E. Anderson
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
Nature Communications
author_facet Qinchuan Wang
Erick O. Hernández-Ochoa
Meera C. Viswanathan
Ian D. Blum
Danh C. Do
Jonathan M. Granger
Kevin R. Murphy
An-Chi Wei
Susan Aja
Naili Liu
Corina M. Antonescu
Liliana D. Florea
C. Conover Talbot
David Mohr
Kathryn R. Wagner
Sergi Regot
Richard M. Lovering
Peisong Gao
Mario A. Bianchet
Mark N. Wu
Anthony Cammarato
Martin F. Schneider
Gabriel S. Bever
Mark E. Anderson
author_sort Qinchuan Wang
title CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
title_short CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
title_full CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
title_fullStr CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
title_full_unstemmed CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
title_sort camkii oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan.
url https://doi.org/10.1038/s41467-021-23549-3
work_keys_str_mv AT qinchuanwang camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT erickohernandezochoa camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT meeracviswanathan camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT iandblum camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT danhcdo camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT jonathanmgranger camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT kevinrmurphy camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT anchiwei camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT susanaja camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT naililiu camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT corinamantonescu camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT lilianadflorea camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT cconovertalbot camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT davidmohr camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT kathrynrwagner camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT sergiregot camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT richardmlovering camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT peisonggao camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT marioabianchet camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT marknwu camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT anthonycammarato camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT martinfschneider camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT gabrielsbever camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
AT markeanderson camkiioxidationisacriticalperformancediseasetradeoffacquiredatthedawnofvertebrateevolution
_version_ 1721420597334900736

Similar Items