Biophysical parameters modification could overcome essential hearing gaps.

• Main Authors: A Kern, C Heid, W-H Steeb, N Stoop, R Stoop
• Format: Article
• Language: English
• Published: Public Library of Science (PLoS) 2008-08-01
• Series: PLoS Computational Biology
• Online Access: http://europepmc.org/articles/PMC2516184?pdf=render

A majority of hearing defects are due to malfunction of the outer hair cells (OHCs), those cells within the mammalian hearing sensor (the cochlea) that provide an active amplification of the incoming signal. Malformation of the hearing sensor, ototoxic drugs, acoustical trauma, infections, or the effect of aging affect often a whole frequency interval, which leads to a substantial loss of speech intelligibility. Using an energy-based biophysical model of the passive cochlea, we obtain an explicit description of the dependence of the tonotopic map on the biophysical parameters of the cochlea. Our findings indicate the possibility that by suitable local modifications of the biophysical parameters by microsurgery, even very salient gaps of the tonotopic map could be bridged.