<it>LRRK2</it> knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

<it>LRRK2</it> knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

<p>Abstract</p> <p>Mutations in the <it>LRRK2</it> gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of <it>LRRK2</it> mutations are still not clear, data emerging from <it>in vitro<...

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Bibliographic Details
Main Authors: Hinkle Kelly M, Yue Mei, Behrouz Bahareh, Dächsel Justus C, Lincoln Sarah J, Bowles Erin E, Beevers Joel E, Dugger Brittany, Winner Beate, Prots Iryna, Kent Caroline B, Nishioka Kenya, Lin Wen-Lang, Dickson Dennis W, Janus Christopher J, Farrer Matthew J, Melrose Heather L
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Knockout
Dopamine
Microdialysis
Neuropathology
Open-field
Motor co-ordination
Kidney
Autophagy
Online Access:http://www.molecularneurodegeneration.com/content/7/1/25

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