Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case report
Purpose: To report the findings of unilateral cystoid macular edema (CME) associated with bilateral sub-foveal hyperreflectivity in a patient previously diagnosed with breast cancer and treated with docetaxel and cyclophosphamide. Observations: A 69-year-old female on docetaxel and cyclophosphamide...
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doaj-6c33178271f0454f8f25a0f2c20794722020-12-21T04:47:40ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-12-0120100995Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case reportLaura A. Torrado0George D. Fivgas1Louisiana State University (LSU) School of Medicine, New Orleans, LA, USALouisiana State University (LSU) School of Medicine, New Orleans, LA, USA; The Retina Center, 7777 Hennessy Blvd, Suite 3000. Baton Rouge, LA, 70808, USA; Corresponding author. LSU Department of Ophthalmology, Retina Division, The Retina Center, 7777 Hennessy Blvd, Suite 3000 Baton Rouge, LA, 70808, USAPurpose: To report the findings of unilateral cystoid macular edema (CME) associated with bilateral sub-foveal hyperreflectivity in a patient previously diagnosed with breast cancer and treated with docetaxel and cyclophosphamide. Observations: A 69-year-old female on docetaxel and cyclophosphamide chemotherapy treatment for breast cancer developed blurry vision 20 days after initiation of therapy. Ophthalmic examination revealed reduced visual acuity with bilateral retinal pigment epithelium mottling and annular sub-foveal thickening in the left eye. Optical coherence tomography (OCT) showed cystoid macular changes in the right eye and central sub-macular hyperreflectivity of outer layers in both eyes. Six-months after discontinuation of therapy, OCT findings remained unchanged and visual acuity did not improve. Conclusionsand importance: CME may occur in patients taking taxanes, but this finding associated with sub-macular hyperreflectivity of the outer layers in diagnostic testing has never been reported before. Sub-macular deposits found in this patient may be responsible for decreased vision and did not respond to cessation of therapy.http://www.sciencedirect.com/science/article/pii/S2451993620303108DocetaxelCystoid macular edemaSubfoveal hyperreflectivityOcular toxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura A. Torrado George D. Fivgas |
spellingShingle |
Laura A. Torrado George D. Fivgas Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case report American Journal of Ophthalmology Case Reports Docetaxel Cystoid macular edema Subfoveal hyperreflectivity Ocular toxicity |
author_facet |
Laura A. Torrado George D. Fivgas |
author_sort |
Laura A. Torrado |
title |
Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case report |
title_short |
Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case report |
title_full |
Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case report |
title_fullStr |
Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case report |
title_full_unstemmed |
Unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: A case report |
title_sort |
unilateral cystoid macular edema and bilateral subfoveal hyperreflectivity following docetaxel chemotherapy: a case report |
publisher |
Elsevier |
series |
American Journal of Ophthalmology Case Reports |
issn |
2451-9936 |
publishDate |
2020-12-01 |
description |
Purpose: To report the findings of unilateral cystoid macular edema (CME) associated with bilateral sub-foveal hyperreflectivity in a patient previously diagnosed with breast cancer and treated with docetaxel and cyclophosphamide. Observations: A 69-year-old female on docetaxel and cyclophosphamide chemotherapy treatment for breast cancer developed blurry vision 20 days after initiation of therapy. Ophthalmic examination revealed reduced visual acuity with bilateral retinal pigment epithelium mottling and annular sub-foveal thickening in the left eye. Optical coherence tomography (OCT) showed cystoid macular changes in the right eye and central sub-macular hyperreflectivity of outer layers in both eyes. Six-months after discontinuation of therapy, OCT findings remained unchanged and visual acuity did not improve. Conclusionsand importance: CME may occur in patients taking taxanes, but this finding associated with sub-macular hyperreflectivity of the outer layers in diagnostic testing has never been reported before. Sub-macular deposits found in this patient may be responsible for decreased vision and did not respond to cessation of therapy. |
topic |
Docetaxel Cystoid macular edema Subfoveal hyperreflectivity Ocular toxicity |
url |
http://www.sciencedirect.com/science/article/pii/S2451993620303108 |
work_keys_str_mv |
AT lauraatorrado unilateralcystoidmacularedemaandbilateralsubfovealhyperreflectivityfollowingdocetaxelchemotherapyacasereport AT georgedfivgas unilateralcystoidmacularedemaandbilateralsubfovealhyperreflectivityfollowingdocetaxelchemotherapyacasereport |
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