Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections

Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections

Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison...

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Main Authors: Arsham Ghavasieh, Sebastiano Bontorin, Oriol Artime, Nina Verstraete, Manlio De Domenico
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Communications Physics
Online Access:https://doi.org/10.1038/s42005-021-00582-8
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spelling doaj-6c3ec879512740d28f17babc13acf0d42021-04-25T11:23:38ZengNature Publishing GroupCommunications Physics2399-36502021-04-014111310.1038/s42005-021-00582-8Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infectionsArsham Ghavasieh0Sebastiano Bontorin1Oriol Artime2Nina Verstraete3Manlio De Domenico4Fondazione Bruno KesslerFondazione Bruno KesslerFondazione Bruno KesslerCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 Inserm, ERL5294 CNRSFondazione Bruno KesslerCharacterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID-19 exhibits properties typical of systemic diseases.https://doi.org/10.1038/s42005-021-00582-8
collection DOAJ
language English
format Article
sources DOAJ
author Arsham Ghavasieh
Sebastiano Bontorin
Oriol Artime
Nina Verstraete
Manlio De Domenico
spellingShingle Arsham Ghavasieh
Sebastiano Bontorin
Oriol Artime
Nina Verstraete
Manlio De Domenico
Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
Communications Physics
author_facet Arsham Ghavasieh
Sebastiano Bontorin
Oriol Artime
Nina Verstraete
Manlio De Domenico
author_sort Arsham Ghavasieh
title Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_short Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_full Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_fullStr Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_full_unstemmed Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_sort multiscale statistical physics of the pan-viral interactome unravels the systemic nature of sars-cov-2 infections
publisher Nature Publishing Group
series Communications Physics
issn 2399-3650
publishDate 2021-04-01
description Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID-19 exhibits properties typical of systemic diseases.
url https://doi.org/10.1038/s42005-021-00582-8
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AT sebastianobontorin multiscalestatisticalphysicsofthepanviralinteractomeunravelsthesystemicnatureofsarscov2infections
AT oriolartime multiscalestatisticalphysicsofthepanviralinteractomeunravelsthesystemicnatureofsarscov2infections
AT ninaverstraete multiscalestatisticalphysicsofthepanviralinteractomeunravelsthesystemicnatureofsarscov2infections
AT manliodedomenico multiscalestatisticalphysicsofthepanviralinteractomeunravelsthesystemicnatureofsarscov2infections
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