Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic Republic
Background: Even though measles vaccination was introduced in the Lao PDR in 1984, coverage rates remain consistently low and outbreaks continue to occur frequently. This study was performed to investigate the seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated children f...
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doaj-6c42ebf5afad40ec89e22c46fb5cbabd2021-07-23T04:47:38ZengElsevierInternational Journal of Infectious Diseases1201-97122021-07-01108524530Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic RepublicLisa Hefele0Kinnaly Xaydalasouk1Daria Kleine2Anousin Homsana3Dalouny Xayavong4Sengdavanh Syphan5Judith M. Hübschen6Claude P. Muller7Antony P. Black8Luxembourg Institute of Health, Esch-sur-Alzette, LuxembourgLao-Lux Laboratory, Institut Pasteur du Laos, Vientiane, LaosLuxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Lao-Lux Laboratory, Institut Pasteur du Laos, Vientiane, LaosLao Tropical and Public Health Institute, Vientiane, LaosLao Tropical and Public Health Institute, Vientiane, LaosLao Tropical and Public Health Institute, Vientiane, LaosLuxembourg Institute of Health, Esch-sur-Alzette, LuxembourgLuxembourg Institute of Health, Esch-sur-Alzette, LuxembourgLao-Lux Laboratory, Institut Pasteur du Laos, Vientiane, Laos; Corresponding author.Background: Even though measles vaccination was introduced in the Lao PDR in 1984, coverage rates remain consistently low and outbreaks continue to occur frequently. This study was performed to investigate the seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated children from Central Lao PDR. Methods: Antibody titres of 1090 children aged 8–29 months who were vaccinated at different levels of the health care system were assessed by ELISA. Bivariate and multivariable analyses were performed to identify factors affecting seropositivity against measles and rubella. Results: Among the vaccinated children, 67.5% in Vientiane Province and 76.4% in Bolikhamxay Province were double positive/borderline for measles and rubella IgG. A high proportion of unvaccinated children at both study sites (24.4% and 38.4%) were positive/borderline for measles and/or rubella. Time since vaccination <180 days, more than two siblings, and a mother who is a farmer/labourer were negatively associated with seropositivity. Conclusions: A high prevalence of measles and rubella antibodies was found in unvaccinated children, indicating widespread circulation of both viruses and underreporting of cases. The high proportion of vaccinated children still susceptible to measles suggests problems with vaccine immunogenicity, emphasizing the need for regular evaluations of vaccine efficacy and management.http://www.sciencedirect.com/science/article/pii/S1201971221005051MeaslesRubellaImmunogenicityVaccinationImmunizationChild health |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lisa Hefele Kinnaly Xaydalasouk Daria Kleine Anousin Homsana Dalouny Xayavong Sengdavanh Syphan Judith M. Hübschen Claude P. Muller Antony P. Black |
spellingShingle |
Lisa Hefele Kinnaly Xaydalasouk Daria Kleine Anousin Homsana Dalouny Xayavong Sengdavanh Syphan Judith M. Hübschen Claude P. Muller Antony P. Black Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic Republic International Journal of Infectious Diseases Measles Rubella Immunogenicity Vaccination Immunization Child health |
author_facet |
Lisa Hefele Kinnaly Xaydalasouk Daria Kleine Anousin Homsana Dalouny Xayavong Sengdavanh Syphan Judith M. Hübschen Claude P. Muller Antony P. Black |
author_sort |
Lisa Hefele |
title |
Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic Republic |
title_short |
Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic Republic |
title_full |
Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic Republic |
title_fullStr |
Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic Republic |
title_full_unstemmed |
Seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the Lao People’s Democratic Republic |
title_sort |
seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated infants in the lao people’s democratic republic |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-07-01 |
description |
Background: Even though measles vaccination was introduced in the Lao PDR in 1984, coverage rates remain consistently low and outbreaks continue to occur frequently. This study was performed to investigate the seroprevalence of measles and rubella antibodies in vaccinated and unvaccinated children from Central Lao PDR. Methods: Antibody titres of 1090 children aged 8–29 months who were vaccinated at different levels of the health care system were assessed by ELISA. Bivariate and multivariable analyses were performed to identify factors affecting seropositivity against measles and rubella. Results: Among the vaccinated children, 67.5% in Vientiane Province and 76.4% in Bolikhamxay Province were double positive/borderline for measles and rubella IgG. A high proportion of unvaccinated children at both study sites (24.4% and 38.4%) were positive/borderline for measles and/or rubella. Time since vaccination <180 days, more than two siblings, and a mother who is a farmer/labourer were negatively associated with seropositivity. Conclusions: A high prevalence of measles and rubella antibodies was found in unvaccinated children, indicating widespread circulation of both viruses and underreporting of cases. The high proportion of vaccinated children still susceptible to measles suggests problems with vaccine immunogenicity, emphasizing the need for regular evaluations of vaccine efficacy and management. |
topic |
Measles Rubella Immunogenicity Vaccination Immunization Child health |
url |
http://www.sciencedirect.com/science/article/pii/S1201971221005051 |
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