Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy
Abstract Over recent years, the development of new antibiotics has not kept pace with the rate at which bacteria develop resistance to these drugs. For this reason, many research groups have begun to design and study alternative therapeutics, including molecules to specifically inhibit the virulence...
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doaj-6c4aa8280e4541399e3296691adeae072020-11-25T02:11:18ZengBMCJournal of Biological Engineering1754-16112019-02-0113111410.1186/s13036-018-0138-zInhibition of bacterial toxin recognition of membrane components as an anti-virulence strategyEric Krueger0Angela C. Brown1Department of Chemical and Biomolecular Engineering, Lehigh UniversityDepartment of Chemical and Biomolecular Engineering, Lehigh UniversityAbstract Over recent years, the development of new antibiotics has not kept pace with the rate at which bacteria develop resistance to these drugs. For this reason, many research groups have begun to design and study alternative therapeutics, including molecules to specifically inhibit the virulence of pathogenic bacteria. Because many of these pathogenic bacteria release protein toxins, which cause or exacerbate disease, inhibition of the activity of bacterial toxins is a promising anti-virulence strategy. In this review, we describe several approaches to inhibit the initial interactions of bacterial toxins with host cell membrane components. The mechanisms by which toxins interact with the host cell membrane components have been well-studied over the years, leading to the identification of therapeutic targets, which have been exploited in the work described here. We review efforts to inhibit binding to protein receptors and essential membrane lipid components, complex assembly, and pore formation. Although none of these molecules have yet been demonstrated in clinical trials, the in vitro and in vivo results presented here demonstrate their promise as novel alternatives and/or complements to traditional antibiotics.http://link.springer.com/article/10.1186/s13036-018-0138-zBacterial toxinAnti-virulenceCell membraneReceptor decoysAntibiotic resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eric Krueger Angela C. Brown |
spellingShingle |
Eric Krueger Angela C. Brown Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy Journal of Biological Engineering Bacterial toxin Anti-virulence Cell membrane Receptor decoys Antibiotic resistance |
author_facet |
Eric Krueger Angela C. Brown |
author_sort |
Eric Krueger |
title |
Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy |
title_short |
Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy |
title_full |
Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy |
title_fullStr |
Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy |
title_full_unstemmed |
Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy |
title_sort |
inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy |
publisher |
BMC |
series |
Journal of Biological Engineering |
issn |
1754-1611 |
publishDate |
2019-02-01 |
description |
Abstract Over recent years, the development of new antibiotics has not kept pace with the rate at which bacteria develop resistance to these drugs. For this reason, many research groups have begun to design and study alternative therapeutics, including molecules to specifically inhibit the virulence of pathogenic bacteria. Because many of these pathogenic bacteria release protein toxins, which cause or exacerbate disease, inhibition of the activity of bacterial toxins is a promising anti-virulence strategy. In this review, we describe several approaches to inhibit the initial interactions of bacterial toxins with host cell membrane components. The mechanisms by which toxins interact with the host cell membrane components have been well-studied over the years, leading to the identification of therapeutic targets, which have been exploited in the work described here. We review efforts to inhibit binding to protein receptors and essential membrane lipid components, complex assembly, and pore formation. Although none of these molecules have yet been demonstrated in clinical trials, the in vitro and in vivo results presented here demonstrate their promise as novel alternatives and/or complements to traditional antibiotics. |
topic |
Bacterial toxin Anti-virulence Cell membrane Receptor decoys Antibiotic resistance |
url |
http://link.springer.com/article/10.1186/s13036-018-0138-z |
work_keys_str_mv |
AT erickrueger inhibitionofbacterialtoxinrecognitionofmembranecomponentsasanantivirulencestrategy AT angelacbrown inhibitionofbacterialtoxinrecognitionofmembranecomponentsasanantivirulencestrategy |
_version_ |
1724915113650028544 |