DNA end resection requires constitutive sumoylation of CtIP by CBX4

DNA end resection requires constitutive sumoylation of CtIP by CBX4

The choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery. Here the authors show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.

Bibliographic Details
Main Authors: Isabel Soria-Bretones, Cristina Cepeda-García, Cintia Checa-Rodriguez, Vincent Heyer, Bernardo Reina-San-Martin, Evi Soutoglou, Pablo Huertas
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00183-6
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spelling doaj-6c4d8e6d5aac493ba82944e261ae1bdc2021-01-31T12:48:26ZengNature Publishing GroupNature Communications2041-17232017-07-018111110.1038/s41467-017-00183-6DNA end resection requires constitutive sumoylation of CtIP by CBX4Isabel Soria-Bretones0Cristina Cepeda-García1Cintia Checa-Rodriguez2Vincent Heyer3Bernardo Reina-San-Martin4Evi Soutoglou5Pablo Huertas6Departamento de Genética, Universidad de SevillaCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de OlavideDepartamento de Genética, Universidad de SevillaInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireDepartamento de Genética, Universidad de SevillaThe choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery. Here the authors show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.https://doi.org/10.1038/s41467-017-00183-6
collection DOAJ
language English
format Article
sources DOAJ
author Isabel Soria-Bretones
Cristina Cepeda-García
Cintia Checa-Rodriguez
Vincent Heyer
Bernardo Reina-San-Martin
Evi Soutoglou
Pablo Huertas
spellingShingle Isabel Soria-Bretones
Cristina Cepeda-García
Cintia Checa-Rodriguez
Vincent Heyer
Bernardo Reina-San-Martin
Evi Soutoglou
Pablo Huertas
DNA end resection requires constitutive sumoylation of CtIP by CBX4
Nature Communications
author_facet Isabel Soria-Bretones
Cristina Cepeda-García
Cintia Checa-Rodriguez
Vincent Heyer
Bernardo Reina-San-Martin
Evi Soutoglou
Pablo Huertas
author_sort Isabel Soria-Bretones
title DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_short DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_full DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_fullStr DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_full_unstemmed DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_sort dna end resection requires constitutive sumoylation of ctip by cbx4
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-07-01
description The choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery. Here the authors show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.
url https://doi.org/10.1038/s41467-017-00183-6
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