Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience
Introduction: Spermatic cord sarcomas represent a rare genitourinary malignancy with a challenging diagnostic and therapeutic pathway. Different histotypes have been described and prognostic factors remain poorly defined due to the paucity of data presented in literature.Methods: Retrospective chart...
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doaj-6c50b9a48f344ea9ad5cfb8f35df866d2020-11-25T04:02:44ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2020-11-01710.3389/fsurg.2020.566408566408Spermatic Cord Sarcoma: A 20-Year Single-Institution ExperienceMassimo Iafrate0Giovanni Motterle1Carlotta Zaborra2Niccolò Leone3Tommaso Prayer-Galetti4Filiberto Zattoni5Andrea Guttilla6Rocco Cappellesso7Angelo Paolo Dei Tos8Carlo Riccardo Rossi9Carlo Riccardo Rossi10Paolo Del Fiore11Marco Rastrelli12Simone Mocellin13Simone Mocellin14Urology Clinic Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalyUrology Clinic Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalyUrology Clinic Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalyUrology Clinic Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalyUrology Clinic Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalyUrology Clinic Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, ItalyClinica Urologica dell'Ospedale di Camposampiero, Camposampiero, ItalySurgical Pathology and Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, ItalySurgical Pathology and Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, ItalySurgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, Padua, ItalySurgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, ItalySurgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, ItalySurgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, Padua, ItalyIntroduction: Spermatic cord sarcomas represent a rare genitourinary malignancy with a challenging diagnostic and therapeutic pathway. Different histotypes have been described and prognostic factors remain poorly defined due to the paucity of data presented in literature.Methods: Retrospective chart review of 22 adult patients treated for spermatic cord sarcoma in a single institution in the last 20 years was performed. Clinicopathological characteristics of the tumors were collected with primary and subsequent treatment. Survival analysis was performed in order to identify prognostic factors of disease-specific survival.Results: The median age at diagnosis was 68 years (58–78), the most common histotype was liposarcoma (14/22), and most patients (63.6%) were found to have positive surgical margins after surgery. The 5-year cancer specific survival was 91.3%. Grading (p = 0.480), histotype (p = 0.327), and type of intervention (p = 0.732) were not associated with survival. All patients dead of disease had positive surgical margins (p = 0.172).Conclusion: We report a good prognosis at 5 years. Wide radical resection remains the first and probably the most important step; thus, according also to literature, negative surgical margins should be aimed.https://www.frontiersin.org/articles/10.3389/fsurg.2020.566408/fullsoft tissue sarcomaspermatic cordspermatic cord sarcomaparatesticular sarcomaurologic sarcomatreatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Massimo Iafrate Giovanni Motterle Carlotta Zaborra Niccolò Leone Tommaso Prayer-Galetti Filiberto Zattoni Andrea Guttilla Rocco Cappellesso Angelo Paolo Dei Tos Carlo Riccardo Rossi Carlo Riccardo Rossi Paolo Del Fiore Marco Rastrelli Simone Mocellin Simone Mocellin |
spellingShingle |
Massimo Iafrate Giovanni Motterle Carlotta Zaborra Niccolò Leone Tommaso Prayer-Galetti Filiberto Zattoni Andrea Guttilla Rocco Cappellesso Angelo Paolo Dei Tos Carlo Riccardo Rossi Carlo Riccardo Rossi Paolo Del Fiore Marco Rastrelli Simone Mocellin Simone Mocellin Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience Frontiers in Surgery soft tissue sarcoma spermatic cord spermatic cord sarcoma paratesticular sarcoma urologic sarcoma treatment |
author_facet |
Massimo Iafrate Giovanni Motterle Carlotta Zaborra Niccolò Leone Tommaso Prayer-Galetti Filiberto Zattoni Andrea Guttilla Rocco Cappellesso Angelo Paolo Dei Tos Carlo Riccardo Rossi Carlo Riccardo Rossi Paolo Del Fiore Marco Rastrelli Simone Mocellin Simone Mocellin |
author_sort |
Massimo Iafrate |
title |
Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience |
title_short |
Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience |
title_full |
Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience |
title_fullStr |
Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience |
title_full_unstemmed |
Spermatic Cord Sarcoma: A 20-Year Single-Institution Experience |
title_sort |
spermatic cord sarcoma: a 20-year single-institution experience |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Surgery |
issn |
2296-875X |
publishDate |
2020-11-01 |
description |
Introduction: Spermatic cord sarcomas represent a rare genitourinary malignancy with a challenging diagnostic and therapeutic pathway. Different histotypes have been described and prognostic factors remain poorly defined due to the paucity of data presented in literature.Methods: Retrospective chart review of 22 adult patients treated for spermatic cord sarcoma in a single institution in the last 20 years was performed. Clinicopathological characteristics of the tumors were collected with primary and subsequent treatment. Survival analysis was performed in order to identify prognostic factors of disease-specific survival.Results: The median age at diagnosis was 68 years (58–78), the most common histotype was liposarcoma (14/22), and most patients (63.6%) were found to have positive surgical margins after surgery. The 5-year cancer specific survival was 91.3%. Grading (p = 0.480), histotype (p = 0.327), and type of intervention (p = 0.732) were not associated with survival. All patients dead of disease had positive surgical margins (p = 0.172).Conclusion: We report a good prognosis at 5 years. Wide radical resection remains the first and probably the most important step; thus, according also to literature, negative surgical margins should be aimed. |
topic |
soft tissue sarcoma spermatic cord spermatic cord sarcoma paratesticular sarcoma urologic sarcoma treatment |
url |
https://www.frontiersin.org/articles/10.3389/fsurg.2020.566408/full |
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