High-resolution visualization of H3 variants during replication reveals their controlled recycling

High-resolution visualization of H3 variants during replication reveals their controlled recycling

Epigenetic modifications are a key contributor to cell identity, and their propagation is crucial for proper development. Here the authors use a super-resolution microscopy approach to reveal how histone variants are faithfully transmitted during genome duplication, and reveal an important role for...

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Main Authors: Camille Clément, Guillermo A. Orsi, Alberto Gatto, Ekaterina Boyarchuk, Audrey Forest, Bassam Hajj, Judith Miné-Hattab, Mickaël Garnier, Zachary A. Gurard-Levin, Jean-Pierre Quivy, Geneviève Almouzni
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05697-1
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spelling doaj-6c76f62ba9cb4bb9903ec28038c670812021-05-11T10:29:34ZengNature Publishing GroupNature Communications2041-17232018-08-019111710.1038/s41467-018-05697-1High-resolution visualization of H3 variants during replication reveals their controlled recyclingCamille Clément0Guillermo A. Orsi1Alberto Gatto2Ekaterina Boyarchuk3Audrey Forest4Bassam Hajj5Judith Miné-Hattab6Mickaël Garnier7Zachary A. Gurard-Levin8Jean-Pierre Quivy9Geneviève Almouzni10Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerInstitut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerInstitut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerInstitut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerInstitut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerInstitut Curie, PSL Research University, CNRS, UMR168, Laboratoire Physico-ChimieSorbonne Universités, UPMC Univ Paris 06, CNRS, UMR3664Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR3664Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerInstitut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerInstitut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le CancerEpigenetic modifications are a key contributor to cell identity, and their propagation is crucial for proper development. Here the authors use a super-resolution microscopy approach to reveal how histone variants are faithfully transmitted during genome duplication, and reveal an important role for the histone chaperone ASF1 in the redistribution of parental histones.https://doi.org/10.1038/s41467-018-05697-1
collection DOAJ
language English
format Article
sources DOAJ
author Camille Clément
Guillermo A. Orsi
Alberto Gatto
Ekaterina Boyarchuk
Audrey Forest
Bassam Hajj
Judith Miné-Hattab
Mickaël Garnier
Zachary A. Gurard-Levin
Jean-Pierre Quivy
Geneviève Almouzni
spellingShingle Camille Clément
Guillermo A. Orsi
Alberto Gatto
Ekaterina Boyarchuk
Audrey Forest
Bassam Hajj
Judith Miné-Hattab
Mickaël Garnier
Zachary A. Gurard-Levin
Jean-Pierre Quivy
Geneviève Almouzni
High-resolution visualization of H3 variants during replication reveals their controlled recycling
Nature Communications
author_facet Camille Clément
Guillermo A. Orsi
Alberto Gatto
Ekaterina Boyarchuk
Audrey Forest
Bassam Hajj
Judith Miné-Hattab
Mickaël Garnier
Zachary A. Gurard-Levin
Jean-Pierre Quivy
Geneviève Almouzni
author_sort Camille Clément
title High-resolution visualization of H3 variants during replication reveals their controlled recycling
title_short High-resolution visualization of H3 variants during replication reveals their controlled recycling
title_full High-resolution visualization of H3 variants during replication reveals their controlled recycling
title_fullStr High-resolution visualization of H3 variants during replication reveals their controlled recycling
title_full_unstemmed High-resolution visualization of H3 variants during replication reveals their controlled recycling
title_sort high-resolution visualization of h3 variants during replication reveals their controlled recycling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Epigenetic modifications are a key contributor to cell identity, and their propagation is crucial for proper development. Here the authors use a super-resolution microscopy approach to reveal how histone variants are faithfully transmitted during genome duplication, and reveal an important role for the histone chaperone ASF1 in the redistribution of parental histones.
url https://doi.org/10.1038/s41467-018-05697-1
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