Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid
Introduction: Defining mechanisms governing the diffusion from blood to cerebrospinal fluid is central to understanding immune function in the central nervous system. OBJECTIVE. To describe the dynamics of diffusion of the lectin pathway components from blood to cerebrospinal fluid. Methods: It was...
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Centro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED)
2019-05-01
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Series: | Revista Cubana de Investigaciones Biomédicas |
Online Access: | http://www.revibiomedica.sld.cu/index.php/ibi/article/view/103 |
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doaj-6c7700fb647b4b1d932beb0580f2c39f2020-11-25T02:31:35ZspaCentro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED)Revista Cubana de Investigaciones Biomédicas0864-03001561-30112019-05-01381118Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal FluidAlejandro Ramos-RobledoChristian Meijides MejíasJosé Alejandro Rodríguez PérezAlejandro Mirabal VielVanessa Pérez del VallínAlberto Juan Dorta ContrerasIntroduction: Defining mechanisms governing the diffusion from blood to cerebrospinal fluid is central to understanding immune function in the central nervous system. OBJECTIVE. To describe the dynamics of diffusion of the lectin pathway components from blood to cerebrospinal fluid. Methods: It was organized the information available in PubMed database and of papers from journals, and abstract books from international congresses belongs mainly to Cuban authors all about the lectin pathway of complement including manan-binding lectin (MBL) and ficolins complexed with the MBL-associated serine proteases (MASP2), and of other components like MASP3, Map44 as regulatory components and the different starters like MBL, ficolins and CLLK. Results: All the lectin pathways component are blood derived proteins but at the same time it could be synthesized intrathecally. Most of the protein can be transferred from blood to cerebrospinal fluid in different aggregation forms and some of them can be described as a consuming curve. The control mechanism of regulation the lectin pathway can be followed by molecules as MASP3 and Map44. Conclusions:The under- constructed lectin pathway of the complement system required not only the available information in different journals. It had to be completed by reviewing the congress abstract book and congress website of the last yearshttp://www.revibiomedica.sld.cu/index.php/ibi/article/view/103 |
collection |
DOAJ |
language |
Spanish |
format |
Article |
sources |
DOAJ |
author |
Alejandro Ramos-Robledo Christian Meijides Mejías José Alejandro Rodríguez Pérez Alejandro Mirabal Viel Vanessa Pérez del Vallín Alberto Juan Dorta Contreras |
spellingShingle |
Alejandro Ramos-Robledo Christian Meijides Mejías José Alejandro Rodríguez Pérez Alejandro Mirabal Viel Vanessa Pérez del Vallín Alberto Juan Dorta Contreras Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid Revista Cubana de Investigaciones Biomédicas |
author_facet |
Alejandro Ramos-Robledo Christian Meijides Mejías José Alejandro Rodríguez Pérez Alejandro Mirabal Viel Vanessa Pérez del Vallín Alberto Juan Dorta Contreras |
author_sort |
Alejandro Ramos-Robledo |
title |
Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid |
title_short |
Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid |
title_full |
Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid |
title_fullStr |
Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid |
title_full_unstemmed |
Lectin Pathway Components And Its Transfer From Blood To Cerebrospinal Fluid |
title_sort |
lectin pathway components and its transfer from blood to cerebrospinal fluid |
publisher |
Centro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED) |
series |
Revista Cubana de Investigaciones Biomédicas |
issn |
0864-0300 1561-3011 |
publishDate |
2019-05-01 |
description |
Introduction: Defining mechanisms governing the diffusion from blood to cerebrospinal fluid is central to understanding immune function in the central nervous system. OBJECTIVE. To describe the dynamics of diffusion of the lectin pathway components from blood to cerebrospinal fluid.
Methods: It was organized the information available in PubMed database and of papers from journals, and abstract books from international congresses belongs mainly to Cuban authors all about the lectin pathway of complement including manan-binding lectin (MBL) and ficolins complexed with the MBL-associated serine proteases (MASP2), and of other components like MASP3, Map44 as regulatory components and the different starters like MBL, ficolins and CLLK.
Results: All the lectin pathways component are blood derived proteins but at the same time it could be synthesized intrathecally. Most of the protein can be transferred from blood to cerebrospinal fluid in different aggregation forms and some of them can be described as a consuming curve. The control mechanism of regulation the lectin pathway can be followed by molecules as MASP3 and Map44.
Conclusions:The under- constructed lectin pathway of the complement system required not only the available information in different journals. It had to be completed by reviewing the congress abstract book and congress website of the last years |
url |
http://www.revibiomedica.sld.cu/index.php/ibi/article/view/103 |
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