Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI
Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with N...
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doaj-6c7a4422eae24348939cedcc823e2e9a2021-04-02T01:37:15ZengMDPI AGChildren2227-90672018-06-01567910.3390/children5060079children5060079Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMIGert-Jan van der Heijden0Zhiyue J. Wang1Zili D. Chu2Morey Haymond3Pieter J. J. Sauer4Agneta L. Sunehag5Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USADepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Radiology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USADepartment of Pediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen 9713 GZ, The NetherlandsDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USAHispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat ≥ 27%; n = 15) and Normal BMI and Normal Fat content (N-BMI-NF: body fat < 27%; n = 8). Plasma concentrations of glucose, insulin, adiponectin, leptin and Hs-CRP were determined. Insulin resistance was calculated using an oral glucose tolerance test. Body fat % was measured by DXA and subcutaneous, visceral and hepatic fat by MRI/MRS. The N-BMI-HF girls had increased abdominal and hepatic fat content and increased insulin resistance, plasma leptin and Hs-CRP concentrations (p < 0.05) as compared to their N-BMI-NF counterparts. In N-BMI girls, insulin resistance, plasma insulin and leptin correlated with BMI and body fat % (p < 0.05). This research confirms the necessity of the development of BMI and body fat % cut-off criteria per sex, age and racial/ethnic group based on metabolic risk factors to optimize the effectiveness of metabolic risk screening procedures.http://www.mdpi.com/2227-9067/5/6/79BMIbody fatabdominal fatHispanicinsulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gert-Jan van der Heijden Zhiyue J. Wang Zili D. Chu Morey Haymond Pieter J. J. Sauer Agneta L. Sunehag |
spellingShingle |
Gert-Jan van der Heijden Zhiyue J. Wang Zili D. Chu Morey Haymond Pieter J. J. Sauer Agneta L. Sunehag Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI Children BMI body fat abdominal fat Hispanic insulin resistance |
author_facet |
Gert-Jan van der Heijden Zhiyue J. Wang Zili D. Chu Morey Haymond Pieter J. J. Sauer Agneta L. Sunehag |
author_sort |
Gert-Jan van der Heijden |
title |
Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI |
title_short |
Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI |
title_full |
Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI |
title_fullStr |
Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI |
title_full_unstemmed |
Obesity-Related Metabolic Risk in Sedentary Hispanic Adolescent Girls with Normal BMI |
title_sort |
obesity-related metabolic risk in sedentary hispanic adolescent girls with normal bmi |
publisher |
MDPI AG |
series |
Children |
issn |
2227-9067 |
publishDate |
2018-06-01 |
description |
Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat ≥ 27%; n = 15) and Normal BMI and Normal Fat content (N-BMI-NF: body fat < 27%; n = 8). Plasma concentrations of glucose, insulin, adiponectin, leptin and Hs-CRP were determined. Insulin resistance was calculated using an oral glucose tolerance test. Body fat % was measured by DXA and subcutaneous, visceral and hepatic fat by MRI/MRS. The N-BMI-HF girls had increased abdominal and hepatic fat content and increased insulin resistance, plasma leptin and Hs-CRP concentrations (p < 0.05) as compared to their N-BMI-NF counterparts. In N-BMI girls, insulin resistance, plasma insulin and leptin correlated with BMI and body fat % (p < 0.05). This research confirms the necessity of the development of BMI and body fat % cut-off criteria per sex, age and racial/ethnic group based on metabolic risk factors to optimize the effectiveness of metabolic risk screening procedures. |
topic |
BMI body fat abdominal fat Hispanic insulin resistance |
url |
http://www.mdpi.com/2227-9067/5/6/79 |
work_keys_str_mv |
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