Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery?
<p><strong>Purpose: </strong>Although [<sup>18</sup>F] FDG-positron emission tomography (PET) provides vital information in diagnosing lung malignancies, the inherent uncertainties of standard uptake value (SUV) compromises its confidence. People have attempted to reduc...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
IJCTO
2014-08-01
|
Series: | International Journal of Cancer Therapy and Oncology |
Subjects: | |
Online Access: | http://ijcto.org/index.php/IJCTO/article/view/147 |
id |
doaj-6c7ed35894634fbcaabfc5bdabf65617 |
---|---|
record_format |
Article |
spelling |
doaj-6c7ed35894634fbcaabfc5bdabf656172020-11-25T00:37:43ZengIJCTOInternational Journal of Cancer Therapy and Oncology 2330-40492014-08-012310.14319/ijcto.0203.17105Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery?Charles Shang0Michael E Kasper1Vindu Kathriarachchi2Rashmi K Benda3Joseph H Kleinman4Jeremy Cole5Timothy R Williams6Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL, USA.Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL, USA.Department of Physics, Florida Atlantic University, Boca Raton, FL, USA.Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL, USA.Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL, USA.Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL, USA.Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL, USA.<p><strong>Purpose: </strong>Although [<sup>18</sup>F] FDG-positron emission tomography (PET) provides vital information in diagnosing lung malignancies, the inherent uncertainties of standard uptake value (SUV) compromises its confidence. People have attempted to reduce this uncertainty by comparing the normal tissues, such as liver and spleen. However, those common reference structures may be inappropriate in some cases when pathological conditions exist. Hence, using alternative reference structures becomes valuable in such practice. The purpose of this study is to explore an alternative reference-correction method to reduce the inherent variation of SUV in the tumor or irradiated region. <strong></strong></p><p><strong>Methods</strong>: 106 analyzable FDG-PET scans from 49 cases who received lung SBRT for non-small cell lung cancer were retrospectively analyzed. The follow-up time ranges from 14.5 weeks to 113.2 weeks. The maximal SUV (SUVmax) was measured within the lung lesion or its corresponding region in post-SBRT. SUVmax was then corrected (or divided) by a reference SUV, or the mean SUV of the adjacent aorta, and results in the new SUVcmax. <strong>Results: </strong>SUVcmax of the positive group are significant higher than that of locally controlled cases (5.82 ± 3.10 vs. 1.45 ± 0.55, p = 0.026), while inconsequential differences were identified between the groups (p = 0.086). Respectively 85.2% and 96.3% of locally controlled cases post SBRT showed decreased values in the latter PET using SUVmax and SUVcmax. PET taken 24 weeks or sooner post-SBRT yielded higher uncertainties.</p><p><strong>Conclusion</strong>: Comparing with the conventional SUVmax, the alternative regional background-corrected SUV indicator, SUVcmax of PTV suggests a stronger correlation between low (<2.5 - 3.0) values and the local tumor control post lung SBRT for NSCLC. However, FDG-PET images taken earlier than 24 weeks post-SBRT presents larger variations in SUV of the irradiated region due to underlying radiation induced inflammatory changes, and is not recommended for assessing local tumor control after lung SBRT.</p><p>.....................................................</p><p><strong>Cite this article as:</strong> Shang CY, Kasper ME, Kathriarachchi V, Benda RK, Kleinman JH, Cole J, Williams TR. Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? <em>Int J Cancer Ther Oncol</em> 2014; <strong>2</strong>(4):020317.<br /><strong>DOI</strong>: <a href="http://dx.doi.org/10.14319/ijcto.0203.17" target="_blank"><strong>10.14319/ijcto.0203.17</strong></a></p>http://ijcto.org/index.php/IJCTO/article/view/147Lung SBRT, FDG-PET, Local Control |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Charles Shang Michael E Kasper Vindu Kathriarachchi Rashmi K Benda Joseph H Kleinman Jeremy Cole Timothy R Williams |
spellingShingle |
Charles Shang Michael E Kasper Vindu Kathriarachchi Rashmi K Benda Joseph H Kleinman Jeremy Cole Timothy R Williams Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? International Journal of Cancer Therapy and Oncology Lung SBRT, FDG-PET, Local Control |
author_facet |
Charles Shang Michael E Kasper Vindu Kathriarachchi Rashmi K Benda Joseph H Kleinman Jeremy Cole Timothy R Williams |
author_sort |
Charles Shang |
title |
Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? |
title_short |
Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? |
title_full |
Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? |
title_fullStr |
Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? |
title_full_unstemmed |
Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? |
title_sort |
can an alternative backround-corrected [18f] fluorodeoxyglucose (fdg) standard uptake value (suv) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? |
publisher |
IJCTO |
series |
International Journal of Cancer Therapy and Oncology |
issn |
2330-4049 |
publishDate |
2014-08-01 |
description |
<p><strong>Purpose: </strong>Although [<sup>18</sup>F] FDG-positron emission tomography (PET) provides vital information in diagnosing lung malignancies, the inherent uncertainties of standard uptake value (SUV) compromises its confidence. People have attempted to reduce this uncertainty by comparing the normal tissues, such as liver and spleen. However, those common reference structures may be inappropriate in some cases when pathological conditions exist. Hence, using alternative reference structures becomes valuable in such practice. The purpose of this study is to explore an alternative reference-correction method to reduce the inherent variation of SUV in the tumor or irradiated region. <strong></strong></p><p><strong>Methods</strong>: 106 analyzable FDG-PET scans from 49 cases who received lung SBRT for non-small cell lung cancer were retrospectively analyzed. The follow-up time ranges from 14.5 weeks to 113.2 weeks. The maximal SUV (SUVmax) was measured within the lung lesion or its corresponding region in post-SBRT. SUVmax was then corrected (or divided) by a reference SUV, or the mean SUV of the adjacent aorta, and results in the new SUVcmax. <strong>Results: </strong>SUVcmax of the positive group are significant higher than that of locally controlled cases (5.82 ± 3.10 vs. 1.45 ± 0.55, p = 0.026), while inconsequential differences were identified between the groups (p = 0.086). Respectively 85.2% and 96.3% of locally controlled cases post SBRT showed decreased values in the latter PET using SUVmax and SUVcmax. PET taken 24 weeks or sooner post-SBRT yielded higher uncertainties.</p><p><strong>Conclusion</strong>: Comparing with the conventional SUVmax, the alternative regional background-corrected SUV indicator, SUVcmax of PTV suggests a stronger correlation between low (<2.5 - 3.0) values and the local tumor control post lung SBRT for NSCLC. However, FDG-PET images taken earlier than 24 weeks post-SBRT presents larger variations in SUV of the irradiated region due to underlying radiation induced inflammatory changes, and is not recommended for assessing local tumor control after lung SBRT.</p><p>.....................................................</p><p><strong>Cite this article as:</strong> Shang CY, Kasper ME, Kathriarachchi V, Benda RK, Kleinman JH, Cole J, Williams TR. Can an alternative backround-corrected [18F] fluorodeoxyglucose (FDG) standard uptake value (SUV) be used for monitoring tumor local control following lung cancer stereotactic body radiosurgery? <em>Int J Cancer Ther Oncol</em> 2014; <strong>2</strong>(4):020317.<br /><strong>DOI</strong>: <a href="http://dx.doi.org/10.14319/ijcto.0203.17" target="_blank"><strong>10.14319/ijcto.0203.17</strong></a></p> |
topic |
Lung SBRT, FDG-PET, Local Control |
url |
http://ijcto.org/index.php/IJCTO/article/view/147 |
work_keys_str_mv |
AT charlesshang cananalternativebackroundcorrected18ffluorodeoxyglucosefdgstandarduptakevaluesuvbeusedformonitoringtumorlocalcontrolfollowinglungcancerstereotacticbodyradiosurgery AT michaelekasper cananalternativebackroundcorrected18ffluorodeoxyglucosefdgstandarduptakevaluesuvbeusedformonitoringtumorlocalcontrolfollowinglungcancerstereotacticbodyradiosurgery AT vindukathriarachchi cananalternativebackroundcorrected18ffluorodeoxyglucosefdgstandarduptakevaluesuvbeusedformonitoringtumorlocalcontrolfollowinglungcancerstereotacticbodyradiosurgery AT rashmikbenda cananalternativebackroundcorrected18ffluorodeoxyglucosefdgstandarduptakevaluesuvbeusedformonitoringtumorlocalcontrolfollowinglungcancerstereotacticbodyradiosurgery AT josephhkleinman cananalternativebackroundcorrected18ffluorodeoxyglucosefdgstandarduptakevaluesuvbeusedformonitoringtumorlocalcontrolfollowinglungcancerstereotacticbodyradiosurgery AT jeremycole cananalternativebackroundcorrected18ffluorodeoxyglucosefdgstandarduptakevaluesuvbeusedformonitoringtumorlocalcontrolfollowinglungcancerstereotacticbodyradiosurgery AT timothyrwilliams cananalternativebackroundcorrected18ffluorodeoxyglucosefdgstandarduptakevaluesuvbeusedformonitoringtumorlocalcontrolfollowinglungcancerstereotacticbodyradiosurgery |
_version_ |
1725299789191446528 |