Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study.
Depressive symptoms have become the most important global public health issue. Iron plays an important role in brain function, cognition, and behavior, and its impacts on depressive symptoms may be multifactorial with both positive and negative effects. Previous observational studies focusing on the...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5017657?pdf=render |
id |
doaj-6c82fc630900478e8a02a55ce02168e9 |
---|---|
record_format |
Article |
spelling |
doaj-6c82fc630900478e8a02a55ce02168e92020-11-24T22:11:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e016268210.1371/journal.pone.0162682Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study.Qian SuYeqing GuBin YuFei YuHaiyan HeQing ZhangGe MengHongmei WuHuanmin DuLi LiuHongbin ShiYang XiaXiaoyan GuoXing LiuChunlei LiXue BaoFangfang LiuLiyun FangHuijun YangShaomei SunXing WangMing ZhouQiyu JiaHonglin ZhaoKun SongKaijun NiuDepressive symptoms have become the most important global public health issue. Iron plays an important role in brain function, cognition, and behavior, and its impacts on depressive symptoms may be multifactorial with both positive and negative effects. Previous observational studies focusing on the association between iron status and depressive symptoms showed inconsistent results. Ferritin is a ubiquitous intracellular protein that can store and release iron and is widely used as a clinical biomarker to evaluate iron status. We performed a cross-sectional study to examine the relationship between serum ferritin and depressive symptoms among 3,839 subjects who were from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIHealth) cohort. Depressive symptoms were assessed using the Chinese version of 20-item self-rating Depression Scale (SDS) with 4 cutoffs (40, 45, 48 and 50) to indicate elevated depressive symptoms (40 was the primary cut-off). The prevalence of depressive symptoms was 36.5%, 17.6%, 11.0% and 7.0% for SDS ≥40, ≥45, ≥48 and ≥50, respectively. With the primary cut-off point of 40, multiple potential confounding factors were adjusted and the odds ratios (95% confidence interval) of having elevated depressive symptoms by quartiles of serum ferritin concentrations were 1.00 (reference), 1.10 (0.91, 1.34), 0.81 (0.66, 1.01) and 1.02 (0.81, 1.28) for the first, second, third and fourth quartile, respectively (P for trend = 0.76). Similar relations were observed with the use of other cut-offs as a definition of depressive symptoms. In conclusion, there is no significant relationship between serum ferritin concentrations and depressive symptoms among Chinese adults.http://europepmc.org/articles/PMC5017657?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qian Su Yeqing Gu Bin Yu Fei Yu Haiyan He Qing Zhang Ge Meng Hongmei Wu Huanmin Du Li Liu Hongbin Shi Yang Xia Xiaoyan Guo Xing Liu Chunlei Li Xue Bao Fangfang Liu Liyun Fang Huijun Yang Shaomei Sun Xing Wang Ming Zhou Qiyu Jia Honglin Zhao Kun Song Kaijun Niu |
spellingShingle |
Qian Su Yeqing Gu Bin Yu Fei Yu Haiyan He Qing Zhang Ge Meng Hongmei Wu Huanmin Du Li Liu Hongbin Shi Yang Xia Xiaoyan Guo Xing Liu Chunlei Li Xue Bao Fangfang Liu Liyun Fang Huijun Yang Shaomei Sun Xing Wang Ming Zhou Qiyu Jia Honglin Zhao Kun Song Kaijun Niu Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. PLoS ONE |
author_facet |
Qian Su Yeqing Gu Bin Yu Fei Yu Haiyan He Qing Zhang Ge Meng Hongmei Wu Huanmin Du Li Liu Hongbin Shi Yang Xia Xiaoyan Guo Xing Liu Chunlei Li Xue Bao Fangfang Liu Liyun Fang Huijun Yang Shaomei Sun Xing Wang Ming Zhou Qiyu Jia Honglin Zhao Kun Song Kaijun Niu |
author_sort |
Qian Su |
title |
Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. |
title_short |
Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. |
title_full |
Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. |
title_fullStr |
Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. |
title_full_unstemmed |
Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. |
title_sort |
association between serum ferritin concentrations and depressive symptoms among chinese adults: a population study from the tianjin chronic low-grade systemic inflammation and health (tclsihealth) cohort study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Depressive symptoms have become the most important global public health issue. Iron plays an important role in brain function, cognition, and behavior, and its impacts on depressive symptoms may be multifactorial with both positive and negative effects. Previous observational studies focusing on the association between iron status and depressive symptoms showed inconsistent results. Ferritin is a ubiquitous intracellular protein that can store and release iron and is widely used as a clinical biomarker to evaluate iron status. We performed a cross-sectional study to examine the relationship between serum ferritin and depressive symptoms among 3,839 subjects who were from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIHealth) cohort. Depressive symptoms were assessed using the Chinese version of 20-item self-rating Depression Scale (SDS) with 4 cutoffs (40, 45, 48 and 50) to indicate elevated depressive symptoms (40 was the primary cut-off). The prevalence of depressive symptoms was 36.5%, 17.6%, 11.0% and 7.0% for SDS ≥40, ≥45, ≥48 and ≥50, respectively. With the primary cut-off point of 40, multiple potential confounding factors were adjusted and the odds ratios (95% confidence interval) of having elevated depressive symptoms by quartiles of serum ferritin concentrations were 1.00 (reference), 1.10 (0.91, 1.34), 0.81 (0.66, 1.01) and 1.02 (0.81, 1.28) for the first, second, third and fourth quartile, respectively (P for trend = 0.76). Similar relations were observed with the use of other cut-offs as a definition of depressive symptoms. In conclusion, there is no significant relationship between serum ferritin concentrations and depressive symptoms among Chinese adults. |
url |
http://europepmc.org/articles/PMC5017657?pdf=render |
work_keys_str_mv |
AT qiansu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT yeqinggu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT binyu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT feiyu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT haiyanhe associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT qingzhang associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT gemeng associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT hongmeiwu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT huanmindu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT liliu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT hongbinshi associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT yangxia associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT xiaoyanguo associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT xingliu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT chunleili associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT xuebao associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT fangfangliu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT liyunfang associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT huijunyang associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT shaomeisun associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT xingwang associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT mingzhou associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT qiyujia associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT honglinzhao associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT kunsong associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy AT kaijunniu associationbetweenserumferritinconcentrationsanddepressivesymptomsamongchineseadultsapopulationstudyfromthetianjinchroniclowgradesystemicinflammationandhealthtclsihealthcohortstudy |
_version_ |
1725805719272292352 |