SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum
Summary: COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symp...
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doaj-6c94517cdfc74dbc8bca49abed3a345f2020-11-25T04:08:38ZengElsevieriScience2589-00422020-10-012310101645SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of SerumChiara Bruzzone0Maider Bizkarguenaga1Rubén Gil-Redondo2Tammo Diercks3Eunate Arana4Aitor García de Vicuña5Marisa Seco6Alexandre Bosch7Asís Palazón8Itxaso San Juan9Ana Laín10Jon Gil-Martínez11Ganeko Bernardo-Seisdedos12David Fernández-Ramos13Fernando Lopitz-Otsoa14Nieves Embade15Shelly Lu16José M. Mato17Oscar Millet18Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainNMR Platform, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, Osakidetza, 48903 Barakaldo, SpainBiocruces Bizkaia Health Research Institute, Cruces University Hospital, Osakidetza, 48903 Barakaldo, SpainOSARTEN Kooperativa Elkartea, 20500 Arrasate-Mondragón, SpainCancer Immunology and Immunotherapy Lab, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainCancer Immunology and Immunotherapy Lab, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainATLAS Molecular Pharma S. L., 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, Spain; CIBERehd, Instituto de Salud Carlos III Madrid, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainDivision of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, SpainPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, 48160 Derio, Spain; ATLAS Molecular Pharma S. L., 48160 Derio, Spain; Corresponding authorSummary: COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress.http://www.sciencedirect.com/science/article/pii/S2589004220308373Human MetabolismVirologyMetabolomics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chiara Bruzzone Maider Bizkarguenaga Rubén Gil-Redondo Tammo Diercks Eunate Arana Aitor García de Vicuña Marisa Seco Alexandre Bosch Asís Palazón Itxaso San Juan Ana Laín Jon Gil-Martínez Ganeko Bernardo-Seisdedos David Fernández-Ramos Fernando Lopitz-Otsoa Nieves Embade Shelly Lu José M. Mato Oscar Millet |
spellingShingle |
Chiara Bruzzone Maider Bizkarguenaga Rubén Gil-Redondo Tammo Diercks Eunate Arana Aitor García de Vicuña Marisa Seco Alexandre Bosch Asís Palazón Itxaso San Juan Ana Laín Jon Gil-Martínez Ganeko Bernardo-Seisdedos David Fernández-Ramos Fernando Lopitz-Otsoa Nieves Embade Shelly Lu José M. Mato Oscar Millet SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum iScience Human Metabolism Virology Metabolomics |
author_facet |
Chiara Bruzzone Maider Bizkarguenaga Rubén Gil-Redondo Tammo Diercks Eunate Arana Aitor García de Vicuña Marisa Seco Alexandre Bosch Asís Palazón Itxaso San Juan Ana Laín Jon Gil-Martínez Ganeko Bernardo-Seisdedos David Fernández-Ramos Fernando Lopitz-Otsoa Nieves Embade Shelly Lu José M. Mato Oscar Millet |
author_sort |
Chiara Bruzzone |
title |
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum |
title_short |
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum |
title_full |
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum |
title_fullStr |
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum |
title_full_unstemmed |
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum |
title_sort |
sars-cov-2 infection dysregulates the metabolomic and lipidomic profiles of serum |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2020-10-01 |
description |
Summary: COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress. |
topic |
Human Metabolism Virology Metabolomics |
url |
http://www.sciencedirect.com/science/article/pii/S2589004220308373 |
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