Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma
There has been a drastic increase in detection of lung nodules, many of which are precancers, preinvasive, minimally invasive or sometimes invasive lung cancers. Here, Hu et al. perform multi-region exome sequencing to discern the evolutional trajectory from precancers to invasive lung cancers.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10877-8 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xin Hu Junya Fujimoto Lisha Ying Junya Fukuoka Kazuto Ashizawa Wenyong Sun Alexandre Reuben Chi-Wan Chow Nicholas McGranahan Runzhe Chen Jinlin Hu Myrna C. Godoy Kazuhiro Tabata Kishio Kuroda Lei Shi Jun Li Carmen Behrens Edwin Roger Parra Latasha D. Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L. Thornton Humam Kadara Paul Scheet Emily Roarty Edwin Justin Ostrin Xu Wang Brett W. Carter Mara B. Antonoff Jianhua Zhang Ara A. Vaporciyan Harvey Pass Stephen G. Swisher John V. Heymach J. Jack Lee Ignacio I. Wistuba Waun Ki Hong P. Andrew Futreal Dan Su Jianjun Zhang |
| spellingShingle |
Xin Hu Junya Fujimoto Lisha Ying Junya Fukuoka Kazuto Ashizawa Wenyong Sun Alexandre Reuben Chi-Wan Chow Nicholas McGranahan Runzhe Chen Jinlin Hu Myrna C. Godoy Kazuhiro Tabata Kishio Kuroda Lei Shi Jun Li Carmen Behrens Edwin Roger Parra Latasha D. Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L. Thornton Humam Kadara Paul Scheet Emily Roarty Edwin Justin Ostrin Xu Wang Brett W. Carter Mara B. Antonoff Jianhua Zhang Ara A. Vaporciyan Harvey Pass Stephen G. Swisher John V. Heymach J. Jack Lee Ignacio I. Wistuba Waun Ki Hong P. Andrew Futreal Dan Su Jianjun Zhang Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma Nature Communications |
| author_facet |
Xin Hu Junya Fujimoto Lisha Ying Junya Fukuoka Kazuto Ashizawa Wenyong Sun Alexandre Reuben Chi-Wan Chow Nicholas McGranahan Runzhe Chen Jinlin Hu Myrna C. Godoy Kazuhiro Tabata Kishio Kuroda Lei Shi Jun Li Carmen Behrens Edwin Roger Parra Latasha D. Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L. Thornton Humam Kadara Paul Scheet Emily Roarty Edwin Justin Ostrin Xu Wang Brett W. Carter Mara B. Antonoff Jianhua Zhang Ara A. Vaporciyan Harvey Pass Stephen G. Swisher John V. Heymach J. Jack Lee Ignacio I. Wistuba Waun Ki Hong P. Andrew Futreal Dan Su Jianjun Zhang |
| author_sort |
Xin Hu |
| title |
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma |
| title_short |
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma |
| title_full |
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma |
| title_fullStr |
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma |
| title_full_unstemmed |
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma |
| title_sort |
multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
There has been a drastic increase in detection of lung nodules, many of which are precancers, preinvasive, minimally invasive or sometimes invasive lung cancers. Here, Hu et al. perform multi-region exome sequencing to discern the evolutional trajectory from precancers to invasive lung cancers. |
| url |
https://doi.org/10.1038/s41467-019-10877-8 |
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doaj-6c98a1e227804a168c18ce27f945729f2021-05-11T12:20:26ZengNature Publishing GroupNature Communications2041-17232019-07-0110111010.1038/s41467-019-10877-8Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinomaXin Hu0Junya Fujimoto1Lisha Ying2Junya Fukuoka3Kazuto Ashizawa4Wenyong Sun5Alexandre Reuben6Chi-Wan Chow7Nicholas McGranahan8Runzhe Chen9Jinlin Hu10Myrna C. Godoy11Kazuhiro Tabata12Kishio Kuroda13Lei Shi14Jun Li15Carmen Behrens16Edwin Roger Parra17Latasha D. Little18Curtis Gumbs19Xizeng Mao20Xingzhi Song21Samantha Tippen22Rebecca L. Thornton23Humam Kadara24Paul Scheet25Emily Roarty26Edwin Justin Ostrin27Xu Wang28Brett W. Carter29Mara B. Antonoff30Jianhua Zhang31Ara A. Vaporciyan32Harvey Pass33Stephen G. Swisher34John V. Heymach35J. Jack Lee36Ignacio I. Wistuba37Waun Ki Hong38P. Andrew Futreal39Dan Su40Jianjun Zhang41Department of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterInstitute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital & Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang ProvinceDepartment of Pathology, Nagasaki University Graduate School of Biomedical SciencesDepartment of Clinical Oncology, Nagasaki University Graduate School of Biomedical SciencesDepartment of Pathology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer HospitalDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterCancer Research United Kingdom-University College London Lung Cancer Centre of ExcellenceDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Pathology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer HospitalDepartment of Diagnostic Radiology, The University of Texas MD Anderson Cancer CenterDepartment of Pathology, Nagasaki University Graduate School of Biomedical SciencesDepartment of Pathology, Nagasaki University Graduate School of Biomedical SciencesDepartment of Radiology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer HospitalDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of General Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Radiology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer HospitalDepartment of Diagnostic Radiology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer CenterDepartment of Cardiothoracic Surgery, New York University Langone Medical CenterDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Pathology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer HospitalDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer CenterThere has been a drastic increase in detection of lung nodules, many of which are precancers, preinvasive, minimally invasive or sometimes invasive lung cancers. Here, Hu et al. perform multi-region exome sequencing to discern the evolutional trajectory from precancers to invasive lung cancers.https://doi.org/10.1038/s41467-019-10877-8 |