Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This rev...

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Main Authors:	Mariano A. Scorciapino, Ilaria Serra, Giorgia Manzo, Andrea C. Rinaldi
Format:	Article
Language:	English
Published:	MDPI AG 2017-03-01
Series:	International Journal of Molecular Sciences
Subjects:	antimicrobial peptides dendrimers peptidomimetics biofilms antiviral antifungal antitumor model membranes biophysical methods NMR molecular dynamics
Online Access:	http://www.mdpi.com/1422-0067/18/3/542

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spelling	doaj-6ca0ae01fd054644b0f63e411100db872020-11-24T22:50:04ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-03-0118354210.3390/ijms18030542ijms18030542Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic ApplicationsMariano A. Scorciapino0Ilaria Serra1Giorgia Manzo2Andrea C. Rinaldi3Department of Biomedical Sciences, University of Cagliari, Monserrato I-09042, CA, ItalyDepartment of Chemical and Geological Sciences, University of Cagliari, Monserrato I-09042, CA, ItalyInstitute of Pharmaceutical Science, King’s College London, London SE1 9NH, UKDepartment of Biomedical Sciences, University of Cagliari, Monserrato I-09042, CA, ItalyMicrobial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These intriguing novel compounds, generally made of multiple peptidic sequences linked to an inner branched core, display an array of antibacterial, antiviral and antifungal activities, usually coupled to low haemolytic activity. In addition, several peptides synthesized in oligobranched form proved to be promising tools for the selective treatment of cancer cells.http://www.mdpi.com/1422-0067/18/3/542antimicrobial peptidesdendrimerspeptidomimeticsbiofilmsantiviralantifungalantitumormodel membranesbiophysical methodsNMRmolecular dynamics
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mariano A. Scorciapino Ilaria Serra Giorgia Manzo Andrea C. Rinaldi
spellingShingle	Mariano A. Scorciapino Ilaria Serra Giorgia Manzo Andrea C. Rinaldi Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications International Journal of Molecular Sciences antimicrobial peptides dendrimers peptidomimetics biofilms antiviral antifungal antitumor model membranes biophysical methods NMR molecular dynamics
author_facet	Mariano A. Scorciapino Ilaria Serra Giorgia Manzo Andrea C. Rinaldi
author_sort	Mariano A. Scorciapino
title	Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications
title_short	Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications
title_full	Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications
title_fullStr	Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications
title_full_unstemmed	Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications
title_sort	antimicrobial dendrimeric peptides: structure, activity and new therapeutic applications
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2017-03-01
description	Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These intriguing novel compounds, generally made of multiple peptidic sequences linked to an inner branched core, display an array of antibacterial, antiviral and antifungal activities, usually coupled to low haemolytic activity. In addition, several peptides synthesized in oligobranched form proved to be promising tools for the selective treatment of cancer cells.
topic	antimicrobial peptides dendrimers peptidomimetics biofilms antiviral antifungal antitumor model membranes biophysical methods NMR molecular dynamics
url	http://www.mdpi.com/1422-0067/18/3/542
work_keys_str_mv	AT marianoascorciapino antimicrobialdendrimericpeptidesstructureactivityandnewtherapeuticapplications AT ilariaserra antimicrobialdendrimericpeptidesstructureactivityandnewtherapeuticapplications AT giorgiamanzo antimicrobialdendrimericpeptidesstructureactivityandnewtherapeuticapplications AT andreacrinaldi antimicrobialdendrimericpeptidesstructureactivityandnewtherapeuticapplications
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Antimicrobial Dendrimeric Peptides: Structure, Activity and New Therapeutic Applications

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