Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility?
Cytokines, such as interleukins, are crucial in regulating critical cell signaling pathways as well as being major contributors to inflammatory response and are upregulated during ligament and tendon injuries. The genes encoding key interleukins, such as IL1B and IL6 as well as interleukin receptor...
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doaj-6ca5ee0768344923aa44605d05fd9b2a2020-11-25T02:15:00ZengUniversity of UludagJournal of Sports Science and Medicine1303-29682019-03-01181137145Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility?Ewelina Lulińska-Kuklik, Ewelina Maculewicz, Waldemar Moska, Krzysztof Ficek, Mariusz Kaczmarczyk, Monika Michałowska-Sawczyn, Kinga Humińska-Lisowska, Maciej Buryta, Jakub Chycki, Pawel Cięszczyk, Piotr Żmijewski, Agata Rzeszutko, Marek Sawczuk, Petr Stastny, Miroslav Petr, Agnieszka Maciejewska-Skrendo0Faculty of Medicine, University of Information Technology and Management in Rzeszow, PolandCytokines, such as interleukins, are crucial in regulating critical cell signaling pathways as well as being major contributors to inflammatory response and are upregulated during ligament and tendon injuries. The genes encoding key interleukins, such as IL1B and IL6 as well as interleukin receptor IL6R, were chosen as candidate genes for association with soft tissue injuries. The aim of the case-control study was to verify the hypothesis that sequence variants rs1143627, rs16944, rs1800795, rs2228145 in the IL1B, IL6 and IL6R genes are associated with ACL rupture susceptibility in a Polish population. Among four analyzed SNPs, the rs1800795 IL6 gene polymorphism was found to be the only one significantly associated with ACL rupture (p = 0.010, p = 0.022, p = 0.004 for codominant, recessive and overdominant models, respectively; odds ratio = 1.74, 95% CI 1.08-2.81, sex adjusted p = 0.032 for recessive model). With reference to the other analyzed polymorphisms, we failed to show significant differences in the genotype and allele frequencies for IL6R rs2228145as well as IL1B rs16944 and rs1143627 (analyzed alone or in haplotype combination) between the ACL rupture group and the healthy control group among Polish participants. Due to the nature of case-control studies, the results of this study need to be confirmed in independent studies with larger sample sizes.https://www.jssm.org/hf.php?id=jssm-18-137.xmlSoft tissue injuriesACL ruptureIL1BIL6IL6R |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ewelina Lulińska-Kuklik, Ewelina Maculewicz, Waldemar Moska, Krzysztof Ficek, Mariusz Kaczmarczyk, Monika Michałowska-Sawczyn, Kinga Humińska-Lisowska, Maciej Buryta, Jakub Chycki, Pawel Cięszczyk, Piotr Żmijewski, Agata Rzeszutko, Marek Sawczuk, Petr Stastny, Miroslav Petr, Agnieszka Maciejewska-Skrendo |
spellingShingle |
Ewelina Lulińska-Kuklik, Ewelina Maculewicz, Waldemar Moska, Krzysztof Ficek, Mariusz Kaczmarczyk, Monika Michałowska-Sawczyn, Kinga Humińska-Lisowska, Maciej Buryta, Jakub Chycki, Pawel Cięszczyk, Piotr Żmijewski, Agata Rzeszutko, Marek Sawczuk, Petr Stastny, Miroslav Petr, Agnieszka Maciejewska-Skrendo Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility? Journal of Sports Science and Medicine Soft tissue injuries ACL rupture IL1B IL6 IL6R |
author_facet |
Ewelina Lulińska-Kuklik, Ewelina Maculewicz, Waldemar Moska, Krzysztof Ficek, Mariusz Kaczmarczyk, Monika Michałowska-Sawczyn, Kinga Humińska-Lisowska, Maciej Buryta, Jakub Chycki, Pawel Cięszczyk, Piotr Żmijewski, Agata Rzeszutko, Marek Sawczuk, Petr Stastny, Miroslav Petr, Agnieszka Maciejewska-Skrendo |
author_sort |
Ewelina Lulińska-Kuklik, Ewelina Maculewicz, Waldemar Moska, Krzysztof Ficek, Mariusz Kaczmarczyk, Monika Michałowska-Sawczyn, Kinga Humińska-Lisowska, Maciej Buryta, Jakub Chycki, Pawel Cięszczyk, Piotr Żmijewski, Agata Rzeszutko, Marek Sawczuk, Petr Stastny, Miroslav Petr, Agnieszka Maciejewska-Skrendo |
title |
Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility? |
title_short |
Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility? |
title_full |
Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility? |
title_fullStr |
Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility? |
title_full_unstemmed |
Are IL1B, IL6 and IL6R Gene Variants Associated with Anterior Cruciate Ligament Rupture Susceptibility? |
title_sort |
are il1b, il6 and il6r gene variants associated with anterior cruciate ligament rupture susceptibility? |
publisher |
University of Uludag |
series |
Journal of Sports Science and Medicine |
issn |
1303-2968 |
publishDate |
2019-03-01 |
description |
Cytokines, such as interleukins, are crucial in regulating critical cell signaling pathways as well as being major contributors to inflammatory response and are upregulated during ligament and tendon injuries. The genes encoding key interleukins, such as IL1B and IL6 as well as interleukin receptor IL6R, were chosen as candidate genes for association with soft tissue injuries. The aim of the case-control study was to verify the hypothesis that sequence variants rs1143627, rs16944, rs1800795, rs2228145 in the IL1B, IL6 and IL6R genes are associated with ACL rupture susceptibility in a Polish population. Among four analyzed SNPs, the rs1800795 IL6 gene polymorphism was found to be the only one significantly associated with ACL rupture (p = 0.010, p = 0.022, p = 0.004 for codominant, recessive and overdominant models, respectively; odds ratio = 1.74, 95% CI 1.08-2.81, sex adjusted p = 0.032 for recessive model). With reference to the other analyzed polymorphisms, we failed to show significant differences in the genotype and allele frequencies for IL6R rs2228145as well as IL1B rs16944 and rs1143627 (analyzed alone or in haplotype combination) between the ACL rupture group and the healthy control group among Polish participants. Due to the nature of case-control studies, the results of this study need to be confirmed in independent studies with larger sample sizes. |
topic |
Soft tissue injuries ACL rupture IL1B IL6 IL6R |
url |
https://www.jssm.org/hf.php?id=jssm-18-137.xml |
work_keys_str_mv |
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