SUMOylation-Mediated Response to Mitochondrial Stress
Mitochondrial stress is considered as a factor that reprograms the mitochondrial biogenesis and metabolism. As known, SUMOylation occurs through a series of stress-induced biochemical reactions. During the process of SUMOylation, the small ubiquitin-like modifier (SUMO) and its specific proteases (S...
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doaj-6cafbf94d4824dfbaf5bbf10d4db29442020-11-25T03:07:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-01215657565710.3390/ijms21165657SUMOylation-Mediated Response to Mitochondrial StressJianli He0Jinke Cheng1Tianshi Wang2Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMitochondrial stress is considered as a factor that reprograms the mitochondrial biogenesis and metabolism. As known, SUMOylation occurs through a series of stress-induced biochemical reactions. During the process of SUMOylation, the small ubiquitin-like modifier (SUMO) and its specific proteases (SENPs) are key signal molecules. Furthermore, they are considered as novel mitochondrial stress sensors that respond to the signals produced by various stresses. The responses are critical for mitochondrial homeostasis. The scope of this review is to provide an overview of the function of SUMOylation in the mitochondrial stress response, to delineate a SUMOylation-involved signal network diagram, and to highlight a number of key questions that remain answered.https://www.mdpi.com/1422-0067/21/16/5657SUMOylationSUMOSENPsmitochondrionstress response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jianli He Jinke Cheng Tianshi Wang |
spellingShingle |
Jianli He Jinke Cheng Tianshi Wang SUMOylation-Mediated Response to Mitochondrial Stress International Journal of Molecular Sciences SUMOylation SUMO SENPs mitochondrion stress response |
author_facet |
Jianli He Jinke Cheng Tianshi Wang |
author_sort |
Jianli He |
title |
SUMOylation-Mediated Response to Mitochondrial Stress |
title_short |
SUMOylation-Mediated Response to Mitochondrial Stress |
title_full |
SUMOylation-Mediated Response to Mitochondrial Stress |
title_fullStr |
SUMOylation-Mediated Response to Mitochondrial Stress |
title_full_unstemmed |
SUMOylation-Mediated Response to Mitochondrial Stress |
title_sort |
sumoylation-mediated response to mitochondrial stress |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-08-01 |
description |
Mitochondrial stress is considered as a factor that reprograms the mitochondrial biogenesis and metabolism. As known, SUMOylation occurs through a series of stress-induced biochemical reactions. During the process of SUMOylation, the small ubiquitin-like modifier (SUMO) and its specific proteases (SENPs) are key signal molecules. Furthermore, they are considered as novel mitochondrial stress sensors that respond to the signals produced by various stresses. The responses are critical for mitochondrial homeostasis. The scope of this review is to provide an overview of the function of SUMOylation in the mitochondrial stress response, to delineate a SUMOylation-involved signal network diagram, and to highlight a number of key questions that remain answered. |
topic |
SUMOylation SUMO SENPs mitochondrion stress response |
url |
https://www.mdpi.com/1422-0067/21/16/5657 |
work_keys_str_mv |
AT jianlihe sumoylationmediatedresponsetomitochondrialstress AT jinkecheng sumoylationmediatedresponsetomitochondrialstress AT tianshiwang sumoylationmediatedresponsetomitochondrialstress |
_version_ |
1724668592918626304 |