PCGF5 is required for neural differentiation of embryonic stem cells

PCGF5 is required for neural differentiation of embryonic stem cells

Polycomb-group proteins are key regulators of transcriptional programs that maintain cell identity. Here the authors provide evidence that PCGF5, a subunit of Polycomb Repressor Complex 1, is important for the differentiation of mouse embryonic stem cells towards a neural cell fate.

Bibliographic Details
Main Authors: Mingze Yao, Xueke Zhou, Jiajian Zhou, Shixin Gong, Gongcheng Hu, Jiao Li, Kaimeng Huang, Ping Lai, Guang Shi, Andrew P. Hutchins, Hao Sun, Huating Wang, Hongjie Yao
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03781-0
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spelling doaj-6cb39efe37fb4508942343a70751b98b2021-05-11T09:54:58ZengNature Publishing GroupNature Communications2041-17232018-05-019111210.1038/s41467-018-03781-0PCGF5 is required for neural differentiation of embryonic stem cellsMingze Yao0Xueke Zhou1Jiajian Zhou2Shixin Gong3Gongcheng Hu4Jiao Li5Kaimeng Huang6Ping Lai7Guang Shi8Andrew P. Hutchins9Hao Sun10Huating Wang11Hongjie Yao12CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, the Chinese University of Hong KongCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityDepartment of Biology, Southern University of Science and TechnologyDepartment of Chemical Pathology, Li Ka Shing Institute of Health Sciences, the Chinese University of Hong KongDepartment of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, the Chinese University of Hong KongCAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical UniversityPolycomb-group proteins are key regulators of transcriptional programs that maintain cell identity. Here the authors provide evidence that PCGF5, a subunit of Polycomb Repressor Complex 1, is important for the differentiation of mouse embryonic stem cells towards a neural cell fate.https://doi.org/10.1038/s41467-018-03781-0
collection DOAJ
language English
format Article
sources DOAJ
author Mingze Yao
Xueke Zhou
Jiajian Zhou
Shixin Gong
Gongcheng Hu
Jiao Li
Kaimeng Huang
Ping Lai
Guang Shi
Andrew P. Hutchins
Hao Sun
Huating Wang
Hongjie Yao
spellingShingle Mingze Yao
Xueke Zhou
Jiajian Zhou
Shixin Gong
Gongcheng Hu
Jiao Li
Kaimeng Huang
Ping Lai
Guang Shi
Andrew P. Hutchins
Hao Sun
Huating Wang
Hongjie Yao
PCGF5 is required for neural differentiation of embryonic stem cells
Nature Communications
author_facet Mingze Yao
Xueke Zhou
Jiajian Zhou
Shixin Gong
Gongcheng Hu
Jiao Li
Kaimeng Huang
Ping Lai
Guang Shi
Andrew P. Hutchins
Hao Sun
Huating Wang
Hongjie Yao
author_sort Mingze Yao
title PCGF5 is required for neural differentiation of embryonic stem cells
title_short PCGF5 is required for neural differentiation of embryonic stem cells
title_full PCGF5 is required for neural differentiation of embryonic stem cells
title_fullStr PCGF5 is required for neural differentiation of embryonic stem cells
title_full_unstemmed PCGF5 is required for neural differentiation of embryonic stem cells
title_sort pcgf5 is required for neural differentiation of embryonic stem cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-05-01
description Polycomb-group proteins are key regulators of transcriptional programs that maintain cell identity. Here the authors provide evidence that PCGF5, a subunit of Polycomb Repressor Complex 1, is important for the differentiation of mouse embryonic stem cells towards a neural cell fate.
url https://doi.org/10.1038/s41467-018-03781-0
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AT xuekezhou pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT jiajianzhou pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT shixingong pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT gongchenghu pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT jiaoli pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT kaimenghuang pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT pinglai pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT guangshi pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT andrewphutchins pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT haosun pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
AT huatingwang pcgf5isrequiredforneuraldifferentiationofembryonicstemcells
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