Synchronous Upper and Lower Gastrointestinal Mucosa-Associated Lymphoid Tissue Lymphomas

• Main Authors: Michael McFarlane, John Lin Hieng Wong, Shankara Paneesha, Zbigniew Rudzki, Ramesh Arasaradnam, Chuka Nwokolo
• Format: Article
• Language: English
• Published: Karger Publishers 2016-05-01
• Series: Case Reports in Gastroenterology
• Subjects: MALToma; Synchronous; Upper; Lower; Gastrointestinal
• Online Access: http://www.karger.com/Article/FullText/446576

Mucosa-associated lymphoid tissue lymphoma (MALToma) is a subtype of B-cell non-Hodgkin’s lymphoma, comprising ∼17% of all gastrointestinal (GI) tract lymphomas. It is associated with chronic inflammation and autoimmunity, for example Helicobacter pylori gastritis and Sjogren’s syndrome, respectively. Approximately 50% of GI MALTomas occur in the stomach, with small bowel and colonic lesions being less frequent. Synchronous upper and lower GI MALTomas occur rarely, with few cases reported. We present the case of a 73-year-old patient who presented with change in bowel habit and was found to have synchronous multifocal upper and lower GI MALTomas, which did not respond to H. pylori cure or to rituximab therapy, but did respond to a combination of surgery and chemotherapy with rituximab and bendamustine.