LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition.

LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition.

LSD1, a lysine-specific histone demethylase, is overexpressed in several types of cancers and linked to poor outcomes. In breast cancer, the significance of LSD1 overexpression is not clear. We have performed an in silico analysis to assess the relationship of LSD1 expression to clinical outcome. We...

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Bibliographic Details
Main Authors: Satoi Nagasawa, Anna S Sedukhina, Yuko Nakagawa, Ichiro Maeda, Manabu Kubota, Shigeko Ohnuma, Koichiro Tsugawa, Tomohiko Ohta, Marta Roche-Molina, Juan A Bernal, Ana J Narváez, Anand D Jeyasekharan, Ko Sato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4332491?pdf=render

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http://europepmc.org/articles/PMC4332491?pdf=render

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