Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system

Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system

Introduction: Sickle cell disease (SCD) is a monogenic disease and it is estimated that 300,000 infants are born annually with it. Most treatments available are only palliative, whereas the allogeneic hematopoietic stem cell transplantation offers the only potential cure for SCD. Objective: Generati...

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Bibliographic Details
Main Authors: Bárbara C.M.F. Paes, Luiza C.J.R. Stabeli, Péricles N.M. Costa, Maristela Delgado Orellana, Simone Kashima, Dimas Tadeu Covas, Virgínia Picanço-Castro
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Hematology, Transfusion and Cell Therapy
Subjects:
Hematopoietic differentiation
Induced pluripotent stem cell
Sickle cell anemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137920300250

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