Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats
Gan-Sui-Ban-Xia Decoction (GSBXD) was first presented by Zhang Zhongjing in the book Synopsis of Golden Chamber during the Han Dynasty period. The formula was then used for the treatment of persistent fluid retention with floating pulse in Traditional Chinese Medicine (TCM), which in modern medicine...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-05-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/20/5/9295 |
id |
doaj-6ccfc47a83204acda59ad9661a32e42c |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Zhang Dawei Qian Ying Pan Zhenghua Zhu Jing Huang Junzuan Xi Jianming Guo Xueping Zhou Gansheng Zhong Jinao Duan |
spellingShingle |
Yang Zhang Dawei Qian Ying Pan Zhenghua Zhu Jing Huang Junzuan Xi Jianming Guo Xueping Zhou Gansheng Zhong Jinao Duan Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats Molecules Gan-Sui-Ban-Xia Decoction Gansui and Gancao anti-drug combination UPLC–TQ/MS pharmacokinetics influence |
author_facet |
Yang Zhang Dawei Qian Ying Pan Zhenghua Zhu Jing Huang Junzuan Xi Jianming Guo Xueping Zhou Gansheng Zhong Jinao Duan |
author_sort |
Yang Zhang |
title |
Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats |
title_short |
Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats |
title_full |
Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats |
title_fullStr |
Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats |
title_full_unstemmed |
Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal Rats |
title_sort |
comparisons of the pharmacokinetic profile of four bioactive components after oral administration of gan-sui-ban-xia decoction plus-minus gansui and gancao drug combination in normal rats |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2015-05-01 |
description |
Gan-Sui-Ban-Xia Decoction (GSBXD) was first presented by Zhang Zhongjing in the book Synopsis of Golden Chamber during the Han Dynasty period. The formula was then used for the treatment of persistent fluid retention with floating pulse in Traditional Chinese Medicine (TCM), which in modern medicine is known as malignant ascites. Here, a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the determination of glycyrrhizinic acid, liquiritin, paeoniflorin, albiflorin after oral administration of GSBXD plus-minus Gansui and Gancao anti-drug combination to investigate the possible pharmacokinetic profile differences of different prescriptions with GSBXD in normal rats. The differences of pharmacokinetic parameters among groups were tested by the Student’s t-test with p < 0.05 as the level of significance. Significant differences were found between the Gansui and Gancao anti-drug combination and other herbs in GSBXD on pharmacokinetic profile of glycyrrhizinic acid, liquiritin, paeoniflorin and albiflorin. The obtained knowledge might contribute to the rationality of the clinic use of GSBXD and also reveal the compatibility conditions of the Gansui and Gancao anti-drug combination. |
topic |
Gan-Sui-Ban-Xia Decoction Gansui and Gancao anti-drug combination UPLC–TQ/MS pharmacokinetics influence |
url |
http://www.mdpi.com/1420-3049/20/5/9295 |
work_keys_str_mv |
AT yangzhang comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT daweiqian comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT yingpan comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT zhenghuazhu comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT jinghuang comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT junzuanxi comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT jianmingguo comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT xuepingzhou comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT ganshengzhong comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats AT jinaoduan comparisonsofthepharmacokineticprofileoffourbioactivecomponentsafteroraladministrationofgansuibanxiadecoctionplusminusgansuiandgancaodrugcombinationinnormalrats |
_version_ |
1716785480691875840 |
spelling |
doaj-6ccfc47a83204acda59ad9661a32e42c2020-11-24T20:58:34ZengMDPI AGMolecules1420-30492015-05-012059295930810.3390/molecules20059295molecules20059295Comparisons of the Pharmacokinetic Profile of Four Bioactive Components after Oral Administration of Gan-Sui-Ban-Xia Decoction Plus-Minus Gansui and Gancao Drug Combination in Normal RatsYang Zhang0Dawei Qian1Ying Pan2Zhenghua Zhu3Jing Huang4Junzuan Xi5Jianming Guo6Xueping Zhou7Gansheng Zhong8Jinao Duan9Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaThe No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaBasic Medical College, Beijing University of Chinese Medicine, Beijing 100092, ChinaJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaGan-Sui-Ban-Xia Decoction (GSBXD) was first presented by Zhang Zhongjing in the book Synopsis of Golden Chamber during the Han Dynasty period. The formula was then used for the treatment of persistent fluid retention with floating pulse in Traditional Chinese Medicine (TCM), which in modern medicine is known as malignant ascites. Here, a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the determination of glycyrrhizinic acid, liquiritin, paeoniflorin, albiflorin after oral administration of GSBXD plus-minus Gansui and Gancao anti-drug combination to investigate the possible pharmacokinetic profile differences of different prescriptions with GSBXD in normal rats. The differences of pharmacokinetic parameters among groups were tested by the Student’s t-test with p < 0.05 as the level of significance. Significant differences were found between the Gansui and Gancao anti-drug combination and other herbs in GSBXD on pharmacokinetic profile of glycyrrhizinic acid, liquiritin, paeoniflorin and albiflorin. The obtained knowledge might contribute to the rationality of the clinic use of GSBXD and also reveal the compatibility conditions of the Gansui and Gancao anti-drug combination.http://www.mdpi.com/1420-3049/20/5/9295Gan-Sui-Ban-Xia DecoctionGansui and Gancao anti-drug combinationUPLC–TQ/MSpharmacokinetics influence |