Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2?
Trained immunity is a type of non-specific memory-like immune response induced by some pathogens and vaccines, such as BCG, which can confer antigen-independent protection against a wide variety of pathogens. The BCG vaccine has been extensively used to protect against tuberculosis for almost a 100...
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doaj-6cd5ba591fae4051b91255d2f9ad385d2020-11-25T02:14:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.00970548918Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2?Camila Covián0Angello Retamal-Díaz1Susan M. Bueno2Alexis M. Kalergis3Alexis M. Kalergis4Millenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillenium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Endocrinología, Facultad de Medicina, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileTrained immunity is a type of non-specific memory-like immune response induced by some pathogens and vaccines, such as BCG, which can confer antigen-independent protection against a wide variety of pathogens. The BCG vaccine has been extensively used to protect against tuberculosis for almost a 100 years. Interestingly, this vaccine reduces children's mortality caused by infections unrelated to Mycobacterium tuberculosis infection, a phenomenon thought to be due to the induction of trained immunity. The SARS-CoV-2 pandemic has infected, as of April 22, 2020, 2,623,231 people globally, causing a major public health problem worldwide. Currently, no vaccine or treatment is available to control this pandemic. We analyzed the number of positive cases and deaths in different countries and correlated them with the inclusion of BCG vaccination at birth in their national vaccination programs. Interestingly, those countries where BCG vaccination is given at birth have shown a lower contagion rate and fewer COVID-19-related deaths, suggesting that this vaccine may induce trained immunity that could confer some protection for SARS-CoV-2.https://www.frontiersin.org/article/10.3389/fimmu.2020.00970/fullSARS-CoV-2COVID-19BCGinnate immunitytrained immunityvaccine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Camila Covián Angello Retamal-Díaz Susan M. Bueno Alexis M. Kalergis Alexis M. Kalergis |
spellingShingle |
Camila Covián Angello Retamal-Díaz Susan M. Bueno Alexis M. Kalergis Alexis M. Kalergis Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2? Frontiers in Immunology SARS-CoV-2 COVID-19 BCG innate immunity trained immunity vaccine |
author_facet |
Camila Covián Angello Retamal-Díaz Susan M. Bueno Alexis M. Kalergis Alexis M. Kalergis |
author_sort |
Camila Covián |
title |
Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2? |
title_short |
Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2? |
title_full |
Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2? |
title_fullStr |
Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2? |
title_full_unstemmed |
Could BCG Vaccination Induce Protective Trained Immunity for SARS-CoV-2? |
title_sort |
could bcg vaccination induce protective trained immunity for sars-cov-2? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-05-01 |
description |
Trained immunity is a type of non-specific memory-like immune response induced by some pathogens and vaccines, such as BCG, which can confer antigen-independent protection against a wide variety of pathogens. The BCG vaccine has been extensively used to protect against tuberculosis for almost a 100 years. Interestingly, this vaccine reduces children's mortality caused by infections unrelated to Mycobacterium tuberculosis infection, a phenomenon thought to be due to the induction of trained immunity. The SARS-CoV-2 pandemic has infected, as of April 22, 2020, 2,623,231 people globally, causing a major public health problem worldwide. Currently, no vaccine or treatment is available to control this pandemic. We analyzed the number of positive cases and deaths in different countries and correlated them with the inclusion of BCG vaccination at birth in their national vaccination programs. Interestingly, those countries where BCG vaccination is given at birth have shown a lower contagion rate and fewer COVID-19-related deaths, suggesting that this vaccine may induce trained immunity that could confer some protection for SARS-CoV-2. |
topic |
SARS-CoV-2 COVID-19 BCG innate immunity trained immunity vaccine |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.00970/full |
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