Tanshinone IIA increases the bystander effect of herpes simplex virus thymidine kinase/ganciclovir gene therapy via enhanced gap junctional intercellular communication.
The bystander effect is an intriguing phenomenon by which adjacent cells become sensitized to drug treatment during gene therapy with herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV). This effect is reported to be mediated by gap junctional intercellular communication (GJIC), and there...
Main Authors: | Jianyong Xiao, Guangxian Zhang, Pengxiang Qiu, Xijuan Liu, Yingya Wu, Biaoyan Du, Jiefen Li, Jing Zhou, Jingjing Li, Yuhui Tan |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3701623?pdf=render |
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