A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat Model
The aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb<sup>®</sup>, BCP) used in combination with hyaluronic acid (Hyadent<sup>®</sup>, HyA) gel for regeneration of osseous defects in a rat model. Bilateral femora...
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doaj-6cdf8b24e5164f62b417ce38400ca2a12020-11-25T01:19:53ZengMDPI AGApplied Sciences2076-34172020-03-01105165110.3390/app10051651app10051651A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat ModelAbeer G. Ahmed0Fatin A. Awartani1Abdurahman A. Niazy2John A. Jansen3Hamdan S. Alghamdi4Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaMolecular and Cell Biology Laboratory, College of Dentistry, King Saud University, Riyadh 11454, Saudi ArabiaDepartment of Dentistry—Biomaterials, Radboudumc, 6525EX Nijmegen, The NetherlandsDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaThe aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb<sup>®</sup>, BCP) used in combination with hyaluronic acid (Hyadent<sup>®</sup>, HyA) gel for regeneration of osseous defects in a rat model. Bilateral femoral condylar bone defects (3 mm diameter and 3 mm depth) were created in 40 male Wistar rats. The defects were grafted as group I (BCP only), group II (BCP + HyA), group III (HyA only), and group IV (empty control). At four weeks and 10 weeks, the bone specimens were evaluated using histological and histomorphometrical analyses to identify the newly formed bone area (NF-BA (%)), as well as the remaining BCP particles (R-BCP (%)). Light microscopic examination indicated the absence of an inflammatory reaction within the bone defects after four weeks or 10 weeks of implantation. Significant new bone regeneration was present in the bone defects grafted with BCP or BCP + HyA biomaterials, as early as four weeks, compared to control groups. The addition of HyA to BCP did not significantly improve bone regeneration at four weeks or 10 weeks. Nevertheless, its role in bone healing and regeneration warrants further investigation.https://www.mdpi.com/2076-3417/10/5/1651bone graftsbiphasic calcium phosphatehyaluronic acidanimal model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abeer G. Ahmed Fatin A. Awartani Abdurahman A. Niazy John A. Jansen Hamdan S. Alghamdi |
spellingShingle |
Abeer G. Ahmed Fatin A. Awartani Abdurahman A. Niazy John A. Jansen Hamdan S. Alghamdi A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat Model Applied Sciences bone grafts biphasic calcium phosphate hyaluronic acid animal model |
author_facet |
Abeer G. Ahmed Fatin A. Awartani Abdurahman A. Niazy John A. Jansen Hamdan S. Alghamdi |
author_sort |
Abeer G. Ahmed |
title |
A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat Model |
title_short |
A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat Model |
title_full |
A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat Model |
title_fullStr |
A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat Model |
title_full_unstemmed |
A Combination of Biphasic Calcium Phosphate (Maxresorb<sup>®</sup>) and Hyaluronic Acid Gel (Hyadent<sup>®</sup>) for Repairing Osseous Defects in a Rat Model |
title_sort |
combination of biphasic calcium phosphate (maxresorb<sup>®</sup>) and hyaluronic acid gel (hyadent<sup>®</sup>) for repairing osseous defects in a rat model |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2020-03-01 |
description |
The aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb<sup>®</sup>, BCP) used in combination with hyaluronic acid (Hyadent<sup>®</sup>, HyA) gel for regeneration of osseous defects in a rat model. Bilateral femoral condylar bone defects (3 mm diameter and 3 mm depth) were created in 40 male Wistar rats. The defects were grafted as group I (BCP only), group II (BCP + HyA), group III (HyA only), and group IV (empty control). At four weeks and 10 weeks, the bone specimens were evaluated using histological and histomorphometrical analyses to identify the newly formed bone area (NF-BA (%)), as well as the remaining BCP particles (R-BCP (%)). Light microscopic examination indicated the absence of an inflammatory reaction within the bone defects after four weeks or 10 weeks of implantation. Significant new bone regeneration was present in the bone defects grafted with BCP or BCP + HyA biomaterials, as early as four weeks, compared to control groups. The addition of HyA to BCP did not significantly improve bone regeneration at four weeks or 10 weeks. Nevertheless, its role in bone healing and regeneration warrants further investigation. |
topic |
bone grafts biphasic calcium phosphate hyaluronic acid animal model |
url |
https://www.mdpi.com/2076-3417/10/5/1651 |
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