TNFα drives mitochondrial stress in POMC neurons in obesity

TNFα drives mitochondrial stress in POMC neurons in obesity

Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC ne...

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Main Authors: Chun-Xia Yi, Marc Walter, Yuanqing Gao, Soledad Pitra, Beata Legutko, Stefanie Kälin, Clarita Layritz, Cristina García-Cáceres, Maximilian Bielohuby, Martin Bidlingmaier, Stephen C. Woods, Alexander Ghanem, Karl-Klaus Conzelmann, Javier E. Stern, Martin Jastroch, Matthias H. Tschöp
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15143
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spelling doaj-6cf55e31e14747279bd3ace3419332152021-05-11T07:30:32ZengNature Publishing GroupNature Communications2041-17232017-05-01811910.1038/ncomms15143TNFα drives mitochondrial stress in POMC neurons in obesityChun-Xia Yi0Marc Walter1Yuanqing Gao2Soledad Pitra3Beata Legutko4Stefanie Kälin5Clarita Layritz6Cristina García-Cáceres7Maximilian Bielohuby8Martin Bidlingmaier9Stephen C. Woods10Alexander Ghanem11Karl-Klaus Conzelmann12Javier E. Stern13Martin Jastroch14Matthias H. Tschöp15Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Department of Physiology, Augusta UniversityDivision of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Endocrine Research Unit, Klinikum der Ludwig-Maximilians-UniversitätEndocrine Research Unit, Klinikum der Ludwig-Maximilians-UniversitätDepartment of Psychiatry and Behavioral Neuroscience, University of CincinnatiMax von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-UniversitätMax von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-UniversitätDepartment of Physiology, Augusta UniversityDivision of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.https://doi.org/10.1038/ncomms15143
collection DOAJ
language English
format Article
sources DOAJ
author Chun-Xia Yi
Marc Walter
Yuanqing Gao
Soledad Pitra
Beata Legutko
Stefanie Kälin
Clarita Layritz
Cristina García-Cáceres
Maximilian Bielohuby
Martin Bidlingmaier
Stephen C. Woods
Alexander Ghanem
Karl-Klaus Conzelmann
Javier E. Stern
Martin Jastroch
Matthias H. Tschöp
spellingShingle Chun-Xia Yi
Marc Walter
Yuanqing Gao
Soledad Pitra
Beata Legutko
Stefanie Kälin
Clarita Layritz
Cristina García-Cáceres
Maximilian Bielohuby
Martin Bidlingmaier
Stephen C. Woods
Alexander Ghanem
Karl-Klaus Conzelmann
Javier E. Stern
Martin Jastroch
Matthias H. Tschöp
TNFα drives mitochondrial stress in POMC neurons in obesity
Nature Communications
author_facet Chun-Xia Yi
Marc Walter
Yuanqing Gao
Soledad Pitra
Beata Legutko
Stefanie Kälin
Clarita Layritz
Cristina García-Cáceres
Maximilian Bielohuby
Martin Bidlingmaier
Stephen C. Woods
Alexander Ghanem
Karl-Klaus Conzelmann
Javier E. Stern
Martin Jastroch
Matthias H. Tschöp
author_sort Chun-Xia Yi
title TNFα drives mitochondrial stress in POMC neurons in obesity
title_short TNFα drives mitochondrial stress in POMC neurons in obesity
title_full TNFα drives mitochondrial stress in POMC neurons in obesity
title_fullStr TNFα drives mitochondrial stress in POMC neurons in obesity
title_full_unstemmed TNFα drives mitochondrial stress in POMC neurons in obesity
title_sort tnfα drives mitochondrial stress in pomc neurons in obesity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.
url https://doi.org/10.1038/ncomms15143
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