Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-Spectroscopy
(1) Aim: To evaluate the failure reason and surface modifications of a retrieved knee prosthesis; (2) Methods: Rapid confocal Raman spectroscopy screening was applied on the surface of a retrieved knee prosthesis (both titanium and UHMWPE (Ultra-high-molecular-weight polyethylene) component) in orde...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-08-01
|
Series: | Applied Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3417/10/15/5343 |
id |
doaj-6d03a040e9554019bb86ad890d823a0a |
---|---|
record_format |
Article |
spelling |
doaj-6d03a040e9554019bb86ad890d823a0a2020-11-25T03:48:34ZengMDPI AGApplied Sciences2076-34172020-08-01105343534310.3390/app10155343Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-SpectroscopyCalin Tudor Hozan0Simona Cavalu1Simona Cinta Pinzaru2Aurel George Mohan3Florin Beteg4Gelu Murvai5Faculty of Medicine and Pharmacy, Surgery Department, University of Oradea, P-ta 1Decembrie 10, 410073 Oradea, RomaniaFaculty of Medicine and Pharmacy, Preclinical Sciences Department, University of Oradea, P-ta 1 Decembrie 10, 410073 Oradea, RomaniaBiomolecular Physics Department, Babes-Bolyai University, Kogalniceanu 1, 400084 Cluj-Napoca, RomaniaFaculty of Medicine and Pharmacy, Surgery Department, University of Oradea, P-ta 1Decembrie 10, 410073 Oradea, RomaniaDepartment of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Calea Manastur 3-5, 400372 Cluj-Napoca, RomaniaFaculty of Medicine and Pharmacy, Surgery Department, University of Oradea, P-ta 1Decembrie 10, 410073 Oradea, Romania(1) Aim: To evaluate the failure reason and surface modifications of a retrieved knee prosthesis; (2) Methods: Rapid confocal Raman spectroscopy screening was applied on the surface of a retrieved knee prosthesis (both titanium and UHMWPE (Ultra-high-molecular-weight polyethylene) component) in order to determine predominate implant damage, along with the chemical composition of synovial fluid accumulated in the stem of the tibial component during the implantation period. Correlations between the medical records of the patient (clinical and radiographic information) and spectroscopic results are pointed out, the parameters being interpreted in the context of proper functioning and life span of knee prosthesis; (3) Results: The metallic tibial component does not show any modification during the implantation period, as demonstrated by the well preserved titanium component with signature of anatase phase detected in retrieved component, compared to unused piece. The spectral features of polymeric component (ultrahigh molecular weight polyethylene, UHMWPE) revealed structural modification in crystallinity and amorphous phase accompanied by insignificant level of oxidation (OI < 1). Scratching, pitting and persistent organic spots as a result of mechanical and chemical deterioration were noticed on the surface of retrieved insert. Acrylic cement deterioration was also noticed. Synovial fluid collected from the stem of the tibial component demonstrated a lipidomic profile; (4) Conclusions: Combining the clinical evidences with confocal Raman spectroscopy allowed a rapid screening with high sensitivity and nondestructive measurements in the case of failure in TKA (total knee arthroplasty). The third body wear and lipidomic profile of synovial fluid are cumulative factors of failure in this case, resulting in an osteolysis that finally leads to an aseptic loosening.https://www.mdpi.com/2076-3417/10/15/5343knee prosthesis failurearthroplastyconfocal raman spectroscopy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Calin Tudor Hozan Simona Cavalu Simona Cinta Pinzaru Aurel George Mohan Florin Beteg Gelu Murvai |
spellingShingle |
Calin Tudor Hozan Simona Cavalu Simona Cinta Pinzaru Aurel George Mohan Florin Beteg Gelu Murvai Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-Spectroscopy Applied Sciences knee prosthesis failure arthroplasty confocal raman spectroscopy |
author_facet |
Calin Tudor Hozan Simona Cavalu Simona Cinta Pinzaru Aurel George Mohan Florin Beteg Gelu Murvai |
author_sort |
Calin Tudor Hozan |
title |
Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-Spectroscopy |
title_short |
Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-Spectroscopy |
title_full |
Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-Spectroscopy |
title_fullStr |
Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-Spectroscopy |
title_full_unstemmed |
Rapid Screening of Retrieved Knee Prosthesis Components by Confocal Raman Micro-Spectroscopy |
title_sort |
rapid screening of retrieved knee prosthesis components by confocal raman micro-spectroscopy |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2020-08-01 |
description |
(1) Aim: To evaluate the failure reason and surface modifications of a retrieved knee prosthesis; (2) Methods: Rapid confocal Raman spectroscopy screening was applied on the surface of a retrieved knee prosthesis (both titanium and UHMWPE (Ultra-high-molecular-weight polyethylene) component) in order to determine predominate implant damage, along with the chemical composition of synovial fluid accumulated in the stem of the tibial component during the implantation period. Correlations between the medical records of the patient (clinical and radiographic information) and spectroscopic results are pointed out, the parameters being interpreted in the context of proper functioning and life span of knee prosthesis; (3) Results: The metallic tibial component does not show any modification during the implantation period, as demonstrated by the well preserved titanium component with signature of anatase phase detected in retrieved component, compared to unused piece. The spectral features of polymeric component (ultrahigh molecular weight polyethylene, UHMWPE) revealed structural modification in crystallinity and amorphous phase accompanied by insignificant level of oxidation (OI < 1). Scratching, pitting and persistent organic spots as a result of mechanical and chemical deterioration were noticed on the surface of retrieved insert. Acrylic cement deterioration was also noticed. Synovial fluid collected from the stem of the tibial component demonstrated a lipidomic profile; (4) Conclusions: Combining the clinical evidences with confocal Raman spectroscopy allowed a rapid screening with high sensitivity and nondestructive measurements in the case of failure in TKA (total knee arthroplasty). The third body wear and lipidomic profile of synovial fluid are cumulative factors of failure in this case, resulting in an osteolysis that finally leads to an aseptic loosening. |
topic |
knee prosthesis failure arthroplasty confocal raman spectroscopy |
url |
https://www.mdpi.com/2076-3417/10/15/5343 |
work_keys_str_mv |
AT calintudorhozan rapidscreeningofretrievedkneeprosthesiscomponentsbyconfocalramanmicrospectroscopy AT simonacavalu rapidscreeningofretrievedkneeprosthesiscomponentsbyconfocalramanmicrospectroscopy AT simonacintapinzaru rapidscreeningofretrievedkneeprosthesiscomponentsbyconfocalramanmicrospectroscopy AT aurelgeorgemohan rapidscreeningofretrievedkneeprosthesiscomponentsbyconfocalramanmicrospectroscopy AT florinbeteg rapidscreeningofretrievedkneeprosthesiscomponentsbyconfocalramanmicrospectroscopy AT gelumurvai rapidscreeningofretrievedkneeprosthesiscomponentsbyconfocalramanmicrospectroscopy |
_version_ |
1724498284218679296 |