ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS
Bacteria Klebsiella pneumoniae is one of the most common and dangerous pathogens of human infectious diseases. The research of K. pneumoniae resistance to ß-lactam antibiotics (cephalosporins), which are widely used in anti-infective therapy, is very relevant. The aims of the work is to study K. pne...
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Scientific Сentre for Family Health and Human Reproduction Problems
2017-07-01
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doaj-6d080d3ced4d4626b5f31f5d7a4859c72021-08-17T13:52:57ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962017-07-0124434710.12737/article_59fad513099c94.94562871410ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINSE. V. Anganova0L. A. Raspopina1A. V. Vetokhina2A. V. Dukhanina3Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education; Scientific Center for Family Health and Human Reproduction ProblemsIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education; Irkutsk Regional Clinical Hospital for Infectious DiseasesIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education; Irkutsk Regional Clinical HospitalScientific Center for Family Health and Human Reproduction ProblemsBacteria Klebsiella pneumoniae is one of the most common and dangerous pathogens of human infectious diseases. The research of K. pneumoniae resistance to ß-lactam antibiotics (cephalosporins), which are widely used in anti-infective therapy, is very relevant. The aims of the work is to study K. pneumoniae resistance to cephalosporins. Fifty strains of K. pneumoniae isolated from patients (sputum, lavage liquid, blood) of Irkutsk Regional Clinical Hospital and sectional material in 2015 were examined. Resistance to four antibiotics (cefotaxime, ceftriaxone, ceftazidime, cefepime) was determined by disco-diffusion method. 56.0-62.0 % of K. pneumoniae strains were resistant to drugs of 111 generation cephalosporins; 58.0 % - to drug of 1Vgeneration (cefepime). Klebsiella strains showed the highest resistance to ceftazidime (resistance - 62.0 %; intermediate - 20.0 %). The spectrum of resistance to all four antibiotics was revealed in 52.0 % of strains, cross-resistance - in 64.0 %. The resistance of K. pneumoniae from the sectional material was higher than resistance of Klebsiella isolated from the organs and tissues of the patients. Klebsiella isolated from the lavage fluid more often (p < 0.05) showed resistance to cephalosporins compared to strains isolated from sputum. The research brought us to the conclusion that Klebsiella pneumoniae strains were characterized by a significant level of resistance to ß-lactam antibiotics (cephalosporins).https://www.actabiomedica.ru/jour/article/view/410klebsiella pneumoniaeklebsiella pneumoniaeantibiotic resistancecephalosporins |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E. V. Anganova L. A. Raspopina A. V. Vetokhina A. V. Dukhanina |
spellingShingle |
E. V. Anganova L. A. Raspopina A. V. Vetokhina A. V. Dukhanina ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS Acta Biomedica Scientifica klebsiella pneumoniae klebsiella pneumoniae antibiotic resistance cephalosporins |
author_facet |
E. V. Anganova L. A. Raspopina A. V. Vetokhina A. V. Dukhanina |
author_sort |
E. V. Anganova |
title |
ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS |
title_short |
ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS |
title_full |
ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS |
title_fullStr |
ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS |
title_full_unstemmed |
ANTIBIOTIC RESISTANCE OF KLEBSIELLA PNEUMONIAE TO CEPHALOSPORINS |
title_sort |
antibiotic resistance of klebsiella pneumoniae to cephalosporins |
publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
series |
Acta Biomedica Scientifica |
issn |
2541-9420 2587-9596 |
publishDate |
2017-07-01 |
description |
Bacteria Klebsiella pneumoniae is one of the most common and dangerous pathogens of human infectious diseases. The research of K. pneumoniae resistance to ß-lactam antibiotics (cephalosporins), which are widely used in anti-infective therapy, is very relevant. The aims of the work is to study K. pneumoniae resistance to cephalosporins. Fifty strains of K. pneumoniae isolated from patients (sputum, lavage liquid, blood) of Irkutsk Regional Clinical Hospital and sectional material in 2015 were examined. Resistance to four antibiotics (cefotaxime, ceftriaxone, ceftazidime, cefepime) was determined by disco-diffusion method. 56.0-62.0 % of K. pneumoniae strains were resistant to drugs of 111 generation cephalosporins; 58.0 % - to drug of 1Vgeneration (cefepime). Klebsiella strains showed the highest resistance to ceftazidime (resistance - 62.0 %; intermediate - 20.0 %). The spectrum of resistance to all four antibiotics was revealed in 52.0 % of strains, cross-resistance - in 64.0 %. The resistance of K. pneumoniae from the sectional material was higher than resistance of Klebsiella isolated from the organs and tissues of the patients. Klebsiella isolated from the lavage fluid more often (p < 0.05) showed resistance to cephalosporins compared to strains isolated from sputum. The research brought us to the conclusion that Klebsiella pneumoniae strains were characterized by a significant level of resistance to ß-lactam antibiotics (cephalosporins). |
topic |
klebsiella pneumoniae klebsiella pneumoniae antibiotic resistance cephalosporins |
url |
https://www.actabiomedica.ru/jour/article/view/410 |
work_keys_str_mv |
AT evanganova antibioticresistanceofklebsiellapneumoniaetocephalosporins AT laraspopina antibioticresistanceofklebsiellapneumoniaetocephalosporins AT avvetokhina antibioticresistanceofklebsiellapneumoniaetocephalosporins AT avdukhanina antibioticresistanceofklebsiellapneumoniaetocephalosporins |
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