Position of anticholinergic drugs in the treatment of childhood asthma
Anticholinergic drugs block muscarinic effect of acetylcholine on the receptors of postjunctional membranes and so inhibit the answer of the postganglionic parasympathetic nerve. The loss of M2 muscarinic receptors function occurs in asthmatics and it contributes to bronchial hyperresponsiveness and...
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Serbian Medical Society
2010-01-01
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Series: | Srpski Arhiv za Celokupno Lekarstvo |
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2010/0370-81791006379S.pdf |
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doaj-6d0b911e81824bf89005e01fe35e07e82021-01-02T16:06:13ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792010-01-011385-637938610.2298/SARH1006379SPosition of anticholinergic drugs in the treatment of childhood asthmaStojković-Anđelković AnđelkaObradović SlobodanVuletić BiljanaRadlović VladimirAnticholinergic drugs block muscarinic effect of acetylcholine on the receptors of postjunctional membranes and so inhibit the answer of the postganglionic parasympathetic nerve. The loss of M2 muscarinic receptors function occurs in asthmatics and it contributes to bronchial hyperresponsiveness and it is not a chronic feature of asthma, instead it characterizes asthma exacerbation. The loss of M2 muscarinic receptor function in children and adults happens during antigen bronchoprovocation or during exposition of asthmatics to ozone. After inhalation, ipratropium bromide (IB) can be found in a small quantity in circulation and it links less readily to muscarinic receptors on airway smooth muscles as related to its absorption after intravenous application. In the stepwise approach of asthma inhaled anticholinergics is recommended if the symptoms of the disease cannot be adequately controlled by a regular inhalation of antiinflammatory drugs with β2-agonist and oral steroids. The improvement of the airway inspiratory capacity is more elevated than the improvement of FEV1 after inhalation of IB. IB has similar effect as salbutamol and it is recommended to control a stable chronic obstructive disease. During our numerous investigations and up-to-date experience in the usage of 5-7 μg/kg/body mass of IB repeated every 4-6 hours in combination with salbutamol, we did not notice adverse effects of the drug in infants. IB is recommended for hospital treatment of children. . http://www.doiserbia.nb.rs/img/doi/0370-8179/2010/0370-81791006379S.pdfbronchial asthmaanticholinergicsinfants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stojković-Anđelković Anđelka Obradović Slobodan Vuletić Biljana Radlović Vladimir |
spellingShingle |
Stojković-Anđelković Anđelka Obradović Slobodan Vuletić Biljana Radlović Vladimir Position of anticholinergic drugs in the treatment of childhood asthma Srpski Arhiv za Celokupno Lekarstvo bronchial asthma anticholinergics infants |
author_facet |
Stojković-Anđelković Anđelka Obradović Slobodan Vuletić Biljana Radlović Vladimir |
author_sort |
Stojković-Anđelković Anđelka |
title |
Position of anticholinergic drugs in the treatment of childhood asthma |
title_short |
Position of anticholinergic drugs in the treatment of childhood asthma |
title_full |
Position of anticholinergic drugs in the treatment of childhood asthma |
title_fullStr |
Position of anticholinergic drugs in the treatment of childhood asthma |
title_full_unstemmed |
Position of anticholinergic drugs in the treatment of childhood asthma |
title_sort |
position of anticholinergic drugs in the treatment of childhood asthma |
publisher |
Serbian Medical Society |
series |
Srpski Arhiv za Celokupno Lekarstvo |
issn |
0370-8179 |
publishDate |
2010-01-01 |
description |
Anticholinergic drugs block muscarinic effect of acetylcholine on the receptors of postjunctional membranes and so inhibit the answer of the postganglionic parasympathetic nerve. The loss of M2 muscarinic receptors function occurs in asthmatics and it contributes to bronchial hyperresponsiveness and it is not a chronic feature of asthma, instead it characterizes asthma exacerbation. The loss of M2 muscarinic receptor function in children and adults happens during antigen bronchoprovocation or during exposition of asthmatics to ozone. After inhalation, ipratropium bromide (IB) can be found in a small quantity in circulation and it links less readily to muscarinic receptors on airway smooth muscles as related to its absorption after intravenous application. In the stepwise approach of asthma inhaled anticholinergics is recommended if the symptoms of the disease cannot be adequately controlled by a regular inhalation of antiinflammatory drugs with β2-agonist and oral steroids. The improvement of the airway inspiratory capacity is more elevated than the improvement of FEV1 after inhalation of IB. IB has similar effect as salbutamol and it is recommended to control a stable chronic obstructive disease. During our numerous investigations and up-to-date experience in the usage of 5-7 μg/kg/body mass of IB repeated every 4-6 hours in combination with salbutamol, we did not notice adverse effects of the drug in infants. IB is recommended for hospital treatment of children. . |
topic |
bronchial asthma anticholinergics infants |
url |
http://www.doiserbia.nb.rs/img/doi/0370-8179/2010/0370-81791006379S.pdf |
work_keys_str_mv |
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