Role of cysteines in the stability and DNA-binding activity of the hypochlorite-specific transcription factor HypT.

Role of cysteines in the stability and DNA-binding activity of the hypochlorite-specific transcription factor HypT.

Reactive oxygen species are important components of the immune response. Hypochlorite (HOCl) is produced by neutrophils to kill invading microorganisms. The bactericidal activity of HOCl is due to proteome-wide unfolding and oxidation of proteins at cysteine and methionine residues. Escherichia coli...

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Bibliographic Details
Main Authors: Adrian Drazic, Amelie Tsoutsoulopoulos, Jirka Peschek, Jasmin Gundlach, Maike Krause, Nina C Bach, Katharina M Gebendorfer, Jeannette Winter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792123?pdf=render

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