Glucuronidation of antitumour therapeutics – detoxification, mechanism of resistance or prodrug formation?
The physiological role of phase I and II of xenobiotic biotransformations is their detoxification and better excretion outside the organism. UDP-glucuronosyltransferases (UGTs) being the enzymes of phase II metabolism catalyse the conjugation of glucuronic acid to the lipophilic substrate by its spe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Index Copernicus International S.A.
2015-12-01
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| Series: | Postępy Higieny i Medycyny Doświadczalnej |
| Subjects: | |
| Online Access: | http://phmd.pl/gicid/01.3001.0009.6616 |