Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity
The irregularity and uncertainty of neurophysiologic signals across different time scales can be regarded as neural complexity, which is related to the adaptability of the nervous system and the information processing between neurons. We recently reported general loss of brain complexity, as measure...
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doaj-6d3092086bc94f36b8bd2cef282e520e2020-11-24T22:57:26ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-11-011210.3389/fnins.2018.00826406733Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain ComplexityIntan Low0Intan Low1Po-Chih Kuo2Cheng-Lin Tsai3Yu-Hsiang Liu4Ming-Wei Lin5Hsiang-Tai Chao6Yong-Sheng Chen7Yong-Sheng Chen8Jen-Chuen Hsieh9Jen-Chuen Hsieh10Jen-Chuen Hsieh11Li-Fen Chen12Li-Fen Chen13Li-Fen Chen14Li-Fen Chen15Institute of Brain Science, National Yang-Ming University, Taipei, TaiwanIntegrated Brain Research Unit, Department of Medical Research, Taipei Veterans General Hospital, Taipei, TaiwanInstitute of Statistical Science, Academia Sinica, Taipei, TaiwanInstitute of Biomedical Informatics, National Yang-Ming University, Taipei, TaiwanInstitute of Brain Science, National Yang-Ming University, Taipei, TaiwanInstitute of Public Health, National Yang-Ming University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Computer Science, National Chiao Tung University, Hsinchu, TaiwanCenter for Emergent Functional Matter Science, National Chiao Tung University, Hsinchu, TaiwanInstitute of Brain Science, National Yang-Ming University, Taipei, TaiwanIntegrated Brain Research Unit, Department of Medical Research, Taipei Veterans General Hospital, Taipei, TaiwanBrain Research Center, National Yang-Ming University, Taipei, TaiwanInstitute of Brain Science, National Yang-Ming University, Taipei, TaiwanIntegrated Brain Research Unit, Department of Medical Research, Taipei Veterans General Hospital, Taipei, TaiwanInstitute of Biomedical Informatics, National Yang-Ming University, Taipei, TaiwanBrain Research Center, National Yang-Ming University, Taipei, TaiwanThe irregularity and uncertainty of neurophysiologic signals across different time scales can be regarded as neural complexity, which is related to the adaptability of the nervous system and the information processing between neurons. We recently reported general loss of brain complexity, as measured by multiscale sample entropy (MSE), at pain-related regions in females with primary dysmenorrhea (PDM). However, it is unclear whether this loss of brain complexity is associated with inter-subject genetic variations. Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin in the brain and is crucial to neural plasticity. The BDNF Val66Met single-nucleotide polymorphism (SNP) is associated with mood, stress, and pain conditions. Therefore, we aimed to examine the interactions of BDNF Val66Met polymorphism and long-term menstrual pain experience on brain complexity. We genotyped BDNF Val66Met SNP in 80 PDM females (20 Val/Val, 31 Val/Met, 29 Met/Met) and 76 healthy female controls (25 Val/Val, 36 Val/Met, 15 Met/Met). MSE analysis was applied to neural source activity estimated from resting-state magnetoencephalography (MEG) signals during pain-free state. We found that brain complexity alterations were associated with the interactions of BDNF Val66Met polymorphism and menstrual pain experience. In healthy female controls, Met carriers (Val/Met and Met/Met) demonstrated lower brain complexity than Val/Val homozygotes in extensive brain regions, suggesting a possible protective role of Val/Val homozygosity in brain complexity. However, after experiencing long-term menstrual pain, the complexity differences between different genotypes in healthy controls were greatly diminished in PDM females, especially in the limbic system, including the hippocampus and amygdala. Our results suggest that pain experience preponderantly affects the effect of BDNF Val66Met polymorphism on brain complexity. The results of the present study also highlight the potential utilization of resting-state brain complexity for the development of new therapeutic strategies in patients with chronic pain.https://www.frontiersin.org/article/10.3389/fnins.2018.00826/fullBDNF Val66Met polymorphismprimary dysmenorrheabrain complexitymultiscale entropymagnetoencephalographychronic pain |
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English |
format |
Article |
sources |
DOAJ |
author |
Intan Low Intan Low Po-Chih Kuo Cheng-Lin Tsai Yu-Hsiang Liu Ming-Wei Lin Hsiang-Tai Chao Yong-Sheng Chen Yong-Sheng Chen Jen-Chuen Hsieh Jen-Chuen Hsieh Jen-Chuen Hsieh Li-Fen Chen Li-Fen Chen Li-Fen Chen Li-Fen Chen |
spellingShingle |
Intan Low Intan Low Po-Chih Kuo Cheng-Lin Tsai Yu-Hsiang Liu Ming-Wei Lin Hsiang-Tai Chao Yong-Sheng Chen Yong-Sheng Chen Jen-Chuen Hsieh Jen-Chuen Hsieh Jen-Chuen Hsieh Li-Fen Chen Li-Fen Chen Li-Fen Chen Li-Fen Chen Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity Frontiers in Neuroscience BDNF Val66Met polymorphism primary dysmenorrhea brain complexity multiscale entropy magnetoencephalography chronic pain |
author_facet |
Intan Low Intan Low Po-Chih Kuo Cheng-Lin Tsai Yu-Hsiang Liu Ming-Wei Lin Hsiang-Tai Chao Yong-Sheng Chen Yong-Sheng Chen Jen-Chuen Hsieh Jen-Chuen Hsieh Jen-Chuen Hsieh Li-Fen Chen Li-Fen Chen Li-Fen Chen Li-Fen Chen |
author_sort |
Intan Low |
title |
Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity |
title_short |
Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity |
title_full |
Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity |
title_fullStr |
Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity |
title_full_unstemmed |
Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity |
title_sort |
interactions of bdnf val66met polymorphism and menstrual pain on brain complexity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2018-11-01 |
description |
The irregularity and uncertainty of neurophysiologic signals across different time scales can be regarded as neural complexity, which is related to the adaptability of the nervous system and the information processing between neurons. We recently reported general loss of brain complexity, as measured by multiscale sample entropy (MSE), at pain-related regions in females with primary dysmenorrhea (PDM). However, it is unclear whether this loss of brain complexity is associated with inter-subject genetic variations. Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin in the brain and is crucial to neural plasticity. The BDNF Val66Met single-nucleotide polymorphism (SNP) is associated with mood, stress, and pain conditions. Therefore, we aimed to examine the interactions of BDNF Val66Met polymorphism and long-term menstrual pain experience on brain complexity. We genotyped BDNF Val66Met SNP in 80 PDM females (20 Val/Val, 31 Val/Met, 29 Met/Met) and 76 healthy female controls (25 Val/Val, 36 Val/Met, 15 Met/Met). MSE analysis was applied to neural source activity estimated from resting-state magnetoencephalography (MEG) signals during pain-free state. We found that brain complexity alterations were associated with the interactions of BDNF Val66Met polymorphism and menstrual pain experience. In healthy female controls, Met carriers (Val/Met and Met/Met) demonstrated lower brain complexity than Val/Val homozygotes in extensive brain regions, suggesting a possible protective role of Val/Val homozygosity in brain complexity. However, after experiencing long-term menstrual pain, the complexity differences between different genotypes in healthy controls were greatly diminished in PDM females, especially in the limbic system, including the hippocampus and amygdala. Our results suggest that pain experience preponderantly affects the effect of BDNF Val66Met polymorphism on brain complexity. The results of the present study also highlight the potential utilization of resting-state brain complexity for the development of new therapeutic strategies in patients with chronic pain. |
topic |
BDNF Val66Met polymorphism primary dysmenorrhea brain complexity multiscale entropy magnetoencephalography chronic pain |
url |
https://www.frontiersin.org/article/10.3389/fnins.2018.00826/full |
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