Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.

We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-t...

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Main Authors: Gloria Morizot, Romain Jouffroy, Albert Faye, Paul Chabert, Katia Belhouari, Ruxandra Calin, Caroline Charlier, Patrick Miailhes, Jean-Yves Siriez, Oussama Mouri, Hélène Yera, Jacques Gilquin, Roland Tubiana, Fanny Lanternier, Marie-France Mamzer, Christophe Legendre, Dominique Peyramond, Eric Caumes, Olivier Lortholary, Pierre Buffet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4703342?pdf=render
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spelling doaj-6d4d45c6a517456d849b0991332dcde52020-11-25T02:08:39ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352016-01-01101e000430410.1371/journal.pntd.0004304Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.Gloria MorizotRomain JouffroyAlbert FayePaul ChabertKatia BelhouariRuxandra CalinCaroline CharlierPatrick MiailhesJean-Yves SiriezOussama MouriHélène YeraJacques GilquinRoland TubianaFanny LanternierMarie-France MamzerChristophe LegendreDominique PeyramondEric CaumesOlivier LortholaryPierre BuffetWe report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.http://europepmc.org/articles/PMC4703342?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Gloria Morizot
Romain Jouffroy
Albert Faye
Paul Chabert
Katia Belhouari
Ruxandra Calin
Caroline Charlier
Patrick Miailhes
Jean-Yves Siriez
Oussama Mouri
Hélène Yera
Jacques Gilquin
Roland Tubiana
Fanny Lanternier
Marie-France Mamzer
Christophe Legendre
Dominique Peyramond
Eric Caumes
Olivier Lortholary
Pierre Buffet
spellingShingle Gloria Morizot
Romain Jouffroy
Albert Faye
Paul Chabert
Katia Belhouari
Ruxandra Calin
Caroline Charlier
Patrick Miailhes
Jean-Yves Siriez
Oussama Mouri
Hélène Yera
Jacques Gilquin
Roland Tubiana
Fanny Lanternier
Marie-France Mamzer
Christophe Legendre
Dominique Peyramond
Eric Caumes
Olivier Lortholary
Pierre Buffet
Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
PLoS Neglected Tropical Diseases
author_facet Gloria Morizot
Romain Jouffroy
Albert Faye
Paul Chabert
Katia Belhouari
Ruxandra Calin
Caroline Charlier
Patrick Miailhes
Jean-Yves Siriez
Oussama Mouri
Hélène Yera
Jacques Gilquin
Roland Tubiana
Fanny Lanternier
Marie-France Mamzer
Christophe Legendre
Dominique Peyramond
Eric Caumes
Olivier Lortholary
Pierre Buffet
author_sort Gloria Morizot
title Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
title_short Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
title_full Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
title_fullStr Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
title_full_unstemmed Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
title_sort antimony to cure visceral leishmaniasis unresponsive to liposomal amphotericin b.
publisher Public Library of Science (PLoS)
series PLoS Neglected Tropical Diseases
issn 1935-2727
1935-2735
publishDate 2016-01-01
description We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.
url http://europepmc.org/articles/PMC4703342?pdf=render
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